This study takes its starting point in the question of what makes routines meaningful. Despite the well-established understanding of the importance of both well-functioning routines in primary health care, and the benefits associated with meaningful work, research to date has not integrated the two streams of research. Therefore, the purpose is to increase the understanding of meaningful routines. Based on interviews with three different professional categories in primary healthcare, and a thematic analysis on a latent level, the notion of a two-factor model for meaningful routines is proposed. In the analysis, the two-factor notion is used as a sensitizing concept, and nine factors explaining practitioners' sense of non-meaninglessness and six factors explaining meaningfulness in routines are identified. Thereby, the paper contributes to a better understanding of both what enables a sense of meaningfulness in routines and how different professional roles in the workplace differ in their perceptions. Practically, the results also open for improved routine practices that should consider the individual-collective dichotomy of meaningful routines and the challenge resulting from the fact that what enables meaningfulness in routines for one profession might be what erodes meaningfulness for another.