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Trends in renal function in Northern Sweden 1986-2014: data from the seven cross-sectional surveys within the Northern Sweden MONICA study
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine.
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Clinical chemistry.ORCID iD: 0000-0002-9599-0961
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine.
Renal Medicine, Uppsala University, Uppsala, Sweden.
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2023 (English)In: BMJ Open, E-ISSN 2044-6055, Vol. 13, no 8, article id e072664Article in journal (Refereed) Published
Abstract [en]

Objective: The prevalence of chronic kidney disease (CKD) is increasing globally, and CKD is closely related to cardiovascular disease (CVD). CKD and CVD share several risk factors (RF), such as diabetes, hypertension, obesity and smoking, and the prevalence of these RF has changed during the last decades, and we aimed to study the effect on renal function over time.

Design: Repeated cross-sectional population-based studies.

Setting: The two Northern counties (Norr- and Västerbotten) in Sweden.

Participants: Within the MONitoring Trends and Determinants of CArdiovascular Disease (MONICA) study, seven surveys were performed between 1986 and 2014, including participants aged 25-64 years (n=10 185).

Interventions: None.

Measures: Information on anthropometry, blood pressure and cardiovascular risk factors was collected. Creatinine and cystatin C were analysed in stored blood samples and the estimated glomerular filtration rate (eGFR) calculated using the creatinine-based Lund-Malmö revised and Chronic Kidney Disease Epidemiology Collaboration (eGFR crea) equations as well as the cystatin C-based Caucasian, Asian, Paediatric and Adult cohort (CAPA) equation (eGFR cysC). Renal function over time was analysed using univariable and multivariable linear regression models.

Results: Renal function, both eGFR crea and eGFR cysC, decreased over time (both p<0.001) and differed between counties and sexes. In a multivariable analysis, study year remained inversely associated with both eGFR crea and eGFR cysC (both p<0.001) after adjustment for classical cardiovascular RF.

Conclusion: Renal function has deteriorated in Northern Sweden between 1986 and 2014.

Place, publisher, year, edition, pages
BMJ Publishing Group Ltd, 2023. Vol. 13, no 8, article id e072664
Keywords [en]
epidemiology, nephrology, public health
National Category
Urology and Nephrology
Identifiers
URN: urn:nbn:se:umu:diva-214628DOI: 10.1136/bmjopen-2023-072664PubMedID: 37648389Scopus ID: 2-s2.0-85169231018OAI: oai:DiVA.org:umu-214628DiVA, id: diva2:1799926
Funder
Region VästerbottenEU, FP7, Seventh Framework Programme, HEALTH–F2–2011–278913Available from: 2023-09-25 Created: 2023-09-25 Last updated: 2023-09-25Bibliographically approved

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de Man Lapidoth, JuliaHultdin, JohanJonsson, Andreas P.Wennberg, MariaSöderberg, Stefan

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