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The risk of thromboembolism in patients with muscle invasive bladder cancer before and after cystectomy depending on blood group and neoadjuvant chemotherapy: a multicentre retrospective cohort study
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Urology and Andrology.
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Urology and Andrology.
Department of Clinical and Experimental Medicine, Division of Urology, Linköping University, Linköping, Sweden.
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Urology and Andrology. Department of Surgery, Urology Section, Sundsvall-Härnäsand Hospital, Sundsvall, Sweden.
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2023 (English)In: Journal of Personalized Medicine, E-ISSN 2075-4426, Vol. 13, no 9, article id 1355Article in journal (Refereed) Published
Abstract [en]

PURPOSE: Previous studies have indicated that patients with muscle-invasive bladder cancer with non-O blood types have an increased risk of experiencing thromboembolic events (TEEs). This is finding is in relation to neoadjuvant-chemotherapy (NAC)-naïve patients.

AIM: to establish the risk of TEEs and any association with blood types among NAC patients as well as NAC-naïve patients.

METHODS: Cystectomized patients at four centres treated from 2009 to 2018 (n = 244) were analysed. The quantities of patients corresponding to each blood group were as follows: A-108 (44%); O-99 (41%); B-30 (12%); and AB-7 (3%). NAC patients (n = 167) and NAC-naïve NAC-eligible patients (n = 77) were assessed. In total, 54 women (22%) and 190 men (78%), with a median age of 69 years, were included in the study. The occurrence of any type of TEE from six months pre-cystectomy to 12-24 months after was analysed using logistic regression adjusted for NAC and confounders.

RESULTS: Sixty-six TEEs were detected in 21% of the patients (n = 52). Pulmonary embolus (n = 33) and deep venous thrombosis (n = 11) were the most common forms. No significant differences between blood types were found in the analysis, although B blood type had a nearly significant increased crude risk compared with O blood type, for which there was an OR of 2.48 (95% CI 0.98-6.36). Adjustment for NAC and covariates weakened the OR, which plummeted to 1.98 (95% CI 0.71-5.51).

CONCLUSIONS: No significant associations were found between blood types and TEE occurrences in this cohort including both NAC and NAC-naïve NAC-eligible patients.

Place, publisher, year, edition, pages
MDPI, 2023. Vol. 13, no 9, article id 1355
Keywords [en]
ABO blood group system, complications, cystectomy, neoadjuvant therapy, thromboembolism, urinary bladder neoplasms
National Category
Urology and Nephrology
Identifiers
URN: urn:nbn:se:umu:diva-214814DOI: 10.3390/jpm13091355ISI: 001073713500001PubMedID: 37763123Scopus ID: 2-s2.0-85172903119OAI: oai:DiVA.org:umu-214814DiVA, id: diva2:1801470
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Region Västerbotten, RV-848051Available from: 2023-10-02 Created: 2023-10-02 Last updated: 2024-02-01Bibliographically approved

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Svensson, JohanStyrke, JohanSherif, Amir

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