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Characterising the covariance pattern between lifestyle factors and structural brain measures: a multivariable replication study of two independent ageing cohorts
Danish Research Centre for Magnetic Resonance, centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital–Amager and Hvidovre, Hvidovre, Denmark.
Danish Research Centre for Magnetic Resonance, centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital–Amager and Hvidovre, Hvidovre, Denmark; London Mathematical Laboratory, London, United Kingdom; Department of Psychology, University of Copenhagen, Copenhagen, Denmark.
Danish Research Centre for Magnetic Resonance, centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital–Amager and Hvidovre, Hvidovre, Denmark; Department of Neurology, Copenhagen University Hospital–Bispebjerg and Frederiksberg, Copenhagen, Denmark; Institute for Clinical Medicine, Faculty of Medical and Health Sciences, University of Copenhagen, Copenhagen, Denmark.
Institute of Sports Medicine Copenhagen (ISMC), Copenhagen University Hospital–Bispebjerg and Frederiksberg, Copenhagen, Denmark; Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
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2023 (English)In: Neurobiology of Aging, ISSN 0197-4580, E-ISSN 1558-1497, Vol. 131, p. 115-123Article in journal (Refereed) Published
Abstract [en]

Modifiable lifestyle factors have been shown to promote healthy brain ageing. However, studies have typically focused on a single factor at a time. Given that lifestyle factors do not occur in isolation, multivariable analyses provide a more realistic model of the lifestyle-brain relationship. Here, canonical correlation analyses (CCA) examined the relationship between nine lifestyle factors and seven MRI-derived indices of brain structure. The resulting covariance pattern was further explored with Bayesian regressions. CCA analyses were first conducted on a Danish cohort of older adults (n = 251) and then replicated in a British cohort (n = 668). In both cohorts, the latent factors of lifestyle and brain structure were positively correlated (UK: r =.37, p < 0.001; Denmark: r =.27, p < 0.001). In the cross-validation study, the correlation between lifestyle-brain latent factors was r =.10, p = 0.008. However, the pattern of associations differed between datasets. These findings suggest that baseline characterisation and tailoring towards the study sample may be beneficial for achieving targeted lifestyle interventions.

Place, publisher, year, edition, pages
Elsevier, 2023. Vol. 131, p. 115-123
Keywords [en]
Magnetic resonance imaging (MRI), Modifiable lifestyle factors, Old age, White matter hyperintensities
National Category
Geriatrics
Identifiers
URN: urn:nbn:se:umu:diva-214977DOI: 10.1016/j.neurobiolaging.2023.07.023PubMedID: 37619515Scopus ID: 2-s2.0-85172425623OAI: oai:DiVA.org:umu-214977DiVA, id: diva2:1805009
Funder
Novo Nordisk Foundation, NNF20OC0064869EU, Horizon 2020, 732592Available from: 2023-10-16 Created: 2023-10-16 Last updated: 2023-10-16Bibliographically approved

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Boraxbekk, Carl-Johan

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