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Cryo-XPS for surface characterization of nanomedicines
National Physical Laboratory, Teddington, UK.
National Physical Laboratory, Teddington, UK.
Umeå University, Faculty of Science and Technology, Department of Chemistry.ORCID iD: 0000-0002-4766-2672
Umeå University, Faculty of Science and Technology, Department of Chemistry.ORCID iD: 0000-0003-2646-8501
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2023 (English)In: Journal of Physical Chemistry A, ISSN 1089-5639, E-ISSN 1520-5215, Vol. 127, no 39, p. 8220-8227Article in journal (Refereed) Published
Abstract [en]

Nanoparticles used for medical applications commonly possess coatings or surface functionalities intended to provide specific behavior in vivo, for example, the use of PEG to provide stealth properties. Direct, quantitative measurement of the surface chemistry and composition of such systems in a hydrated environment has thus far not been demonstrated, yet such measurements are of great importance for the development of nanomedicine systems. Here we demonstrate the first use of cryo-XPS for the measurement of two PEG-functionalized nanomedicines: a polymeric drug delivery system and a lipid nanoparticle mRNA carrier. The observed differences between cryo-XPS and standard XPS measurements indicate the potential of cryo-XPS for providing quantitative measurements of such nanoparticle systems in hydrated conditions.

Place, publisher, year, edition, pages
American Chemical Society (ACS), 2023. Vol. 127, no 39, p. 8220-8227
National Category
Analytical Chemistry Materials Chemistry
Identifiers
URN: urn:nbn:se:umu:diva-215315DOI: 10.1021/acs.jpca.3c03879ISI: 001070270700001PubMedID: 37733882Scopus ID: 2-s2.0-85173556161OAI: oai:DiVA.org:umu-215315DiVA, id: diva2:1805405
Funder
EU, Horizon 2020, 825828Available from: 2023-10-17 Created: 2023-10-17 Last updated: 2023-11-06Bibliographically approved

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Shchukarev, AndreyRamstedt, Madeleine

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CiteExportLink to record
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