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Changes in fasting plasma glucose and subclinical atherosclerosis: a cohort study from VIPVIZA trial
Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland; Department of Cardiology, Inselspital, Bern University Hospital, Bern, Switzerland; Graduate School for Health Sciences, University of Bern, Bern, Switzerland.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine.ORCID iD: 0000-0003-2475-7131
Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.
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2023 (English)In: Atherosclerosis, ISSN 0021-9150, E-ISSN 1879-1484, article id 117326Article in journal (Refereed) In press
Abstract [en]

Background and aims: Studies on the influence of fasting plasma glucose (FPG) on the development of carotid plaque (CP) and intima media thickness (CIMT) mainly focused on single FPG measures. We investigated whether changes in FPG (ΔFPG) are associated with incident CP and CIMT change (ΔCIMT) over time.

Methods: Analyses were based on information from 1896 participants from the VIPVIZA trial (Visualization of asymptomatic atherosclerotic disease for optimum cardiovascular prevention), with baseline and 3-year follow-up data on FPG, ultrasonographic CP (none or ≥1 lesion/s) and CIMT assessments. We studied the association between baseline FPG (prior to intervention) or 3-year ΔFPG (mmol/L) and incident CP (logistic regression) or ΔCIMT (linear regression). Analyses were adjusted for multiple potential confounders.

Results: 1896 and 873 individuals, respectively, were included in the analysis on incident CP and ΔCIMT. Participants were 60 years old at baseline and 61% and 54% were females, in the CP and CIMT analyses, respectively. Every mmol/L increase in FPG was associated with an increased odds of incident CP (odds ratio: 1.42, 95% confidence interval [CI]: 1.17, 1.73), but there was no association with ΔCIMT (mean difference: 0.002 mm, 95% CI: −0.003, 0.008) after 3 years. Baseline FPG was not associated with incident CP nor ΔCIMT progression.

Conclusions: In middle-aged individuals with low to moderate risk for cardiovascular diseases, 3-year ΔFPG was positively associated with the risk of incident CP, but not with ΔCIMT. Single measures of FPG may not be sufficient in estimating cardiovascular risk among individuals with low to moderate risk.

Place, publisher, year, edition, pages
Elsevier, 2023. article id 117326
Keywords [en]
Carotid intima media thickness, Carotid plaque, Fasting plasma glucose, Prevention, Subclinical atherosclerosis
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:umu:diva-216637DOI: 10.1016/j.atherosclerosis.2023.117326PubMedID: 37932189Scopus ID: 2-s2.0-85175522942OAI: oai:DiVA.org:umu-216637DiVA, id: diva2:1812619
Funder
EU, Horizon 2020, 801076Available from: 2023-11-16 Created: 2023-11-16 Last updated: 2024-04-26

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Liv, PerNorberg, MargaretaNicoll, RachelNyman, EmmaNäslund, Ulf

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