Umeå University's logo

umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Optic nerve subarachnoid space posture dependency: an MRI study in subjects with normal tension glaucoma and healthy controls
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Ophthalmology.
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Radiation Physics.ORCID iD: 0000-0002-1141-5143
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Ophthalmology.ORCID iD: 0000-0002-3597-4740
Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI). Umeå University, Faculty of Medicine, Department of Radiation Sciences, Radiation Physics.ORCID iD: 0000-0002-2031-722X
Show others and affiliations
2023 (English)In: Investigative Ophthalmology and Visual Science, ISSN 0146-0404, E-ISSN 1552-5783, Vol. 64, no 15, article id 20Article in journal (Refereed) Published
Abstract [en]

Purpose: The purpose of this study was to examine the differences of optic nerve subarachnoid space (ONSAS) volume in patients with normal tension glaucoma (NTG) and healthy controls in different body positions.

Methods: Eight patients with NTG and seven healthy controls underwent magnetic resonance imaging (MRI) examinations in head up tilt (HUT) +11 degrees and head down tilt (HDT) -5 degrees positions according to a randomized protocol determining the starting position. The ONSAS volume in both body positions was measured and compared between the two groups. The results were analyzed using a generalized linear model.

Results: Between HDT and HUT, the postural ONSAS volume change was dependent on starting position (P < 0.001) and group (P = 0.003, NTG versus healthy). A subgroup analysis of those that were randomized to HUT examination first, coming directly from an upright position, showed that the patients with NTG had significantly larger positional ONSAS volume changes compared to the healthy controls; 121 ± 22 µL vs. 65 ± 37 µL (P = 0.049). Analysis of the ONSAS volume distribution showed different profiles for patients with NTG and healthy controls.

Conclusions: There was a significant difference in ONSAS volume change between patients with NTG and healthy subjects when subjected to posture changes, specifically when going from upright to head-down posture. This indicates that patients with NTG had been exposed to a lower ONSAS pressure when they came from the upright posture, which suggests an increased translaminar pressure difference in upright position. This may support the theory that NTG has a dysfunction in an occlusion mechanism of the optic nerve sheath that could cause abnormally negative ONSAS pressures in upright posture.

Place, publisher, year, edition, pages
2023. Vol. 64, no 15, article id 20
Keywords [en]
optic nerve subarachnoid space (ONSAS), glaucoma
National Category
Ophthalmology
Identifiers
URN: urn:nbn:se:umu:diva-218636DOI: 10.1167/iovs.64.15.20PubMedID: 38099734Scopus ID: 2-s2.0-85179765988OAI: oai:DiVA.org:umu-218636DiVA, id: diva2:1822672
Available from: 2023-12-27 Created: 2023-12-27 Last updated: 2024-01-15Bibliographically approved

Open Access in DiVA

fulltext(1008 kB)41 downloads
File information
File name FULLTEXT01.pdfFile size 1008 kBChecksum SHA-512
5f58c71ff24d51161f9cbeca2f45e2678935e1a78d24c28b22e011f596afe769a8cb06acca0ba3271796d33bfe7ca7b5d637a323a37bc17c178bbfec81ecd524
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMedScopus

Authority records

Kristiansen, MartinHolmlund, PetterLinden, ChristinaEklund, AndersJóhannesson, Gauti

Search in DiVA

By author/editor
Kristiansen, MartinHolmlund, PetterLinden, ChristinaEklund, AndersJóhannesson, Gauti
By organisation
OphthalmologyRadiation PhysicsUmeå Centre for Functional Brain Imaging (UFBI)Wallenberg Centre for Molecular Medicine at Umeå University (WCMM)
In the same journal
Investigative Ophthalmology and Visual Science
Ophthalmology

Search outside of DiVA

GoogleGoogle Scholar
Total: 41 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 242 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf