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Pulmonary function and atherosclerosis in the general population: causal associations and clinical implications
Department of Clinical Sciences in Malmö, Lund University, Lund, Sweden.
Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Department of Medical Sciences, Uppsala University, Uppsala, Sweden; Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Huddinge, Sweden; Department of Family Medicine, Kaohsiung Medical University, Kaohsiung City, Taiwan.
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2024 (English)In: European Journal of Epidemiology, ISSN 0393-2990, E-ISSN 1573-7284, Vol. 39, no 1, p. 35-49Article in journal (Refereed) Published
Abstract [en]

Reduced lung function is associated with cardiovascular mortality, but the relationships with atherosclerosis are unclear. The population-based Swedish CArdioPulmonary BioImage study measured lung function, emphysema, coronary CT angiography, coronary calcium, carotid plaques and ankle-brachial index in 29,593 men and women aged 50–64 years. The results were confirmed using 2-sample Mendelian randomization. Lower lung function and emphysema were associated with more atherosclerosis, but these relationships were attenuated after adjustment for cardiovascular risk factors. Lung function was not associated with coronary atherosclerosis in 14,524 never-smokers. No potentially causal effect of lung function on atherosclerosis, or vice versa, was found in the 2-sample Mendelian randomization analysis. Here we show that reduced lung function and atherosclerosis are correlated in the population, but probably not causally related. Assessing lung function in addition to conventional cardiovascular risk factors to gauge risk of subclinical atherosclerosis is probably not meaningful, but low lung function found by chance should alert for atherosclerosis.

Place, publisher, year, edition, pages
Springer Nature, 2024. Vol. 39, no 1, p. 35-49
Keywords [en]
Atherosclerosis, Coronary heart disease, Emphysema, Spirometry
National Category
Cardiac and Cardiovascular Systems Respiratory Medicine and Allergy
Identifiers
URN: urn:nbn:se:umu:diva-219309DOI: 10.1007/s10654-023-01088-zISI: 001132630700001PubMedID: 38165527Scopus ID: 2-s2.0-85181226926OAI: oai:DiVA.org:umu-219309DiVA, id: diva2:1827881
Funder
EU, European Research Council, ERC-2018-STG-801965Swedish Research Council, 2019-01471Swedish Heart Lung Foundation, 20200173Swedish Heart Lung Foundation, 20190505Göran Gustafsson Foundation for Research in Natural Sciences and MedicineAxel och Signe Lagermans donationsstiftelseKnut and Alice Wallenberg FoundationVinnovaUniversity of GothenburgKarolinska InstituteRegion StockholmLinköpings universitetLund UniversityUmeå UniversityUppsala UniversityAvailable from: 2024-01-15 Created: 2024-01-15 Last updated: 2024-05-07Bibliographically approved

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Ahlm, KristinBlomberg, AndersNilsson, UlfRamnemark, AnnaSkoglund Larsson, LinnSöderberg, StefanWaldenström, Anders

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Ahlm, KristinBlomberg, AndersNilsson, UlfRamnemark, AnnaSkoglund Larsson, LinnSöderberg, StefanWaldenström, Anders
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European Journal of Epidemiology
Cardiac and Cardiovascular SystemsRespiratory Medicine and Allergy

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