Umeå University's logo

umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Cerebrovascular pressure reactivity measures: index comparison and clinical outcome in patients with traumatic brain injury treated according to an intracranial pressure–focused management
Department of Clinical Science-Neurosciences, Sweden.
Department of Surgery and Perioperative Sciences, Sweden.
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Radiation Physics.
Department of Clinical Science-Neurosciences, Sweden.
Show others and affiliations
2023 (English)In: Neurotrauma Reports, E-ISSN 2689-288X, Vol. 4, no 1, p. 848-856Article in journal (Refereed) Published
Abstract [en]

The aim was to investigate whether the pressure reactivity indices PRx, long-PRx (L-PRx), and pressure reactivity (PR) are interchangeable as measures of vascular reactivity, and whether they correlate with clinical outcome when an intracranial pressure (ICP)-targeted treatment regimen is applied in patients with traumatic brain injury (TBI). Patients with TBI (n = 29) that arrived at the hospital within 24 h of injury were included. PRx and L-PRx were derived from Pearson correlations between mean arterial pressure (MAP) and ICP over a short- and long-time interval. PR was the regression coefficient between the hourly mean values of ICP and MAP. Indices were compared to each other, parameters at admission, and outcome assessed by the extended Glasgow Outcome Scale-Extended (GOSE) at 6 and 12 months. PRx and L-PRx had the strongest correlation with each other (R = 0.536, p < 0.01). A correlation was also noted between L-PRx and PR (R = 0.475, p < 0.01), but not between PRx and PR. A correlation was found between age and PRx (R = 0.482, p = 0.01). No association with outcome for any of the indices was found. PRx/L-PRx and L-PRx/PR were moderately correlated with each other. Age was associated with PRx. None of the indices correlated with outcome when our ICP treatment regime was applied. Part of our null hypothesis, that the three indices are associated with outcome, must be rejected. There was, however, an association between some of the indices. To further understand the relation of treatment regimes and pressure reactivity indices, a larger, randomized study is warranted.

Place, publisher, year, edition, pages
Mary Ann Liebert, 2023. Vol. 4, no 1, p. 848-856
Keywords [en]
neurointensive care, neurosurgery, pressure reactivity indices, traumatic brain injury
National Category
Neurology
Identifiers
URN: urn:nbn:se:umu:diva-219526DOI: 10.1089/neur.2023.0074Scopus ID: 2-s2.0-85181575401OAI: oai:DiVA.org:umu-219526DiVA, id: diva2:1829942
Available from: 2024-01-22 Created: 2024-01-22 Last updated: 2024-01-22Bibliographically approved

Open Access in DiVA

fulltext(672 kB)35 downloads
File information
File name FULLTEXT01.pdfFile size 672 kBChecksum SHA-512
f1c784e9e9e9037dc1ba7c210f735c9840c573f6e1983d3b4e8cc3bf7b7a59994095f46ac78770cb6833614e5e8e5ece3161ef518b67f4d2164e88291a434f54
Type fulltextMimetype application/pdf

Other links

Publisher's full textScopus

Authority records

Karlsson, MarcusSundström, Nina

Search in DiVA

By author/editor
Karlsson, MarcusSundström, Nina
By organisation
Radiation Physics
Neurology

Search outside of DiVA

GoogleGoogle Scholar
Total: 35 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 182 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf