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Evaluation of extracellular matrix remodeling in full-thickness skin grafts in mice
Umeå University, Faculty of Medicine, Department of Clinical Sciences. Department of Medical Sciences, Clinical Neurophysiology, Uppsala University, Uppsala, Sweden.ORCID iD: 0000-0003-2369-4319
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine.ORCID iD: 0000-0002-3822-0725
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Surgery.ORCID iD: 0000-0002-1033-7489
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Surgery.ORCID iD: 0000-0003-2538-2351
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2024 (English)In: Journal of Histochemistry and Cytochemistry, ISSN 0022-1554, E-ISSN 1551-5044, Vol. 72, no 2, p. 79-94Article in journal (Refereed) Published
Abstract [en]

Abdominal hernia is a protruding weakness in the abdominal wall. It affects abdominal strength and life quality and can lead to complications due to intestinal entrapment. Autologous full-thickness skin graft (FTSG) has recently become an alternative material for reinforcement in the surgical repair of large abdominal hernias instead of synthetic mesh. FTSG eventually integrates with the abdominal wall, but the long-term fate of the graft itself is not fully understood. This has implications as to how these grafts should be optimally used and handled intraoperatively. This study investigates the remodeling of FTSG in either the onlay or the intraperitoneal position 8 weeks after FTSG transplantation in an experimental mouse model. There was a significant presence of fibroblasts, indicated by vimentin and S100A4 staining, but there were significant variations among animals as to how much of the graft had been remodeled into dense connective tissue. This correlated significantly with the proportion of vimentin-positive cells in the dense connective tissue. We also found that collagen hybridizing peptide staining intensity, a marker of active remodeling, was significantly associated with the proportion of S100A4-positive cells in the dense connective tissue of the FTSG.

Place, publisher, year, edition, pages
Sage Publications, 2024. Vol. 72, no 2, p. 79-94
Keywords [en]
collagen, extracellular matrix, fibroblasts, hernia, hyaluronan, mouse model, S100A4, vimentin
National Category
Surgery
Identifiers
URN: urn:nbn:se:umu:diva-221051DOI: 10.1369/00221554231225995ISI: 001147995400001PubMedID: 38264898Scopus ID: 2-s2.0-85184511984OAI: oai:DiVA.org:umu-221051DiVA, id: diva2:1839583
Funder
Swedish Research Council, 2021-00972Region Västerbotten, RV-927121Region Västerbotten, RV-965797Available from: 2024-02-21 Created: 2024-02-21 Last updated: 2024-02-21Bibliographically approved

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Tjust, Anton ErikHellman, UrbanGiannopoulos, AntoniosWinsnes, AnnikaStrigård, KarinGunnarsson, Ulf

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Tjust, Anton ErikHellman, UrbanGiannopoulos, AntoniosWinsnes, AnnikaStrigård, KarinGunnarsson, Ulf
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Department of Clinical SciencesDepartment of Public Health and Clinical MedicineSurgery
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Journal of Histochemistry and Cytochemistry
Surgery

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