Umeå University's logo

umu.sePublikasjoner
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Evaluation of extracellular matrix remodeling in full-thickness skin grafts in mice
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap. Department of Medical Sciences, Clinical Neurophysiology, Uppsala University, Uppsala, Sweden.ORCID-id: 0000-0003-2369-4319
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin.ORCID-id: 0000-0002-3822-0725
Umeå universitet, Medicinska fakulteten, Institutionen för kirurgisk och perioperativ vetenskap, Kirurgi.ORCID-id: 0000-0002-1033-7489
Umeå universitet, Medicinska fakulteten, Institutionen för kirurgisk och perioperativ vetenskap, Kirurgi.ORCID-id: 0000-0003-2538-2351
Vise andre og tillknytning
2024 (engelsk)Inngår i: Journal of Histochemistry and Cytochemistry, ISSN 0022-1554, E-ISSN 1551-5044, Vol. 72, nr 2, s. 79-94Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Abdominal hernia is a protruding weakness in the abdominal wall. It affects abdominal strength and life quality and can lead to complications due to intestinal entrapment. Autologous full-thickness skin graft (FTSG) has recently become an alternative material for reinforcement in the surgical repair of large abdominal hernias instead of synthetic mesh. FTSG eventually integrates with the abdominal wall, but the long-term fate of the graft itself is not fully understood. This has implications as to how these grafts should be optimally used and handled intraoperatively. This study investigates the remodeling of FTSG in either the onlay or the intraperitoneal position 8 weeks after FTSG transplantation in an experimental mouse model. There was a significant presence of fibroblasts, indicated by vimentin and S100A4 staining, but there were significant variations among animals as to how much of the graft had been remodeled into dense connective tissue. This correlated significantly with the proportion of vimentin-positive cells in the dense connective tissue. We also found that collagen hybridizing peptide staining intensity, a marker of active remodeling, was significantly associated with the proportion of S100A4-positive cells in the dense connective tissue of the FTSG.

sted, utgiver, år, opplag, sider
Sage Publications, 2024. Vol. 72, nr 2, s. 79-94
Emneord [en]
collagen, extracellular matrix, fibroblasts, hernia, hyaluronan, mouse model, S100A4, vimentin
HSV kategori
Identifikatorer
URN: urn:nbn:se:umu:diva-221051DOI: 10.1369/00221554231225995ISI: 001147995400001PubMedID: 38264898Scopus ID: 2-s2.0-85184511984OAI: oai:DiVA.org:umu-221051DiVA, id: diva2:1839583
Forskningsfinansiär
Swedish Research Council, 2021-00972Region Västerbotten, RV-927121Region Västerbotten, RV-965797Tilgjengelig fra: 2024-02-21 Laget: 2024-02-21 Sist oppdatert: 2024-02-21bibliografisk kontrollert

Open Access i DiVA

fulltext(3197 kB)34 nedlastinger
Filinformasjon
Fil FULLTEXT01.pdfFilstørrelse 3197 kBChecksum SHA-512
d6d281df179b51e91749e5b6b586aa59811e885e284e20cd5a6c0cb973c8b24ac52ff087b7ddf24f5bbd994e1486b2504f67049cb6d5eb5e821c1491d7972c4c
Type fulltextMimetype application/pdf

Andre lenker

Forlagets fulltekstPubMedScopus

Person

Tjust, Anton ErikHellman, UrbanGiannopoulos, AntoniosWinsnes, AnnikaStrigård, KarinGunnarsson, Ulf

Søk i DiVA

Av forfatter/redaktør
Tjust, Anton ErikHellman, UrbanGiannopoulos, AntoniosWinsnes, AnnikaStrigård, KarinGunnarsson, Ulf
Av organisasjonen
I samme tidsskrift
Journal of Histochemistry and Cytochemistry

Søk utenfor DiVA

GoogleGoogle Scholar
Totalt: 34 nedlastinger
Antall nedlastinger er summen av alle nedlastinger av alle fulltekster. Det kan for eksempel være tidligere versjoner som er ikke lenger tilgjengelige

doi
pubmed
urn-nbn

Altmetric

doi
pubmed
urn-nbn
Totalt: 176 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf