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Computed tomography lesions and their association with global outcome in young people with mild traumatic brain injury
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2023 (English)In: Journal of Neurotrauma, ISSN 0897-7151, E-ISSN 1557-9042, Vol. 40, no 11-12, p. 1243-1254Article in journal (Refereed) Published
Abstract [en]

Mild traumatic brain injury (mTBI) can be accompanied by structural damage to the brain. Here, we investigated how the presence of intracranial traumatic computed tomography (CT) pathologies relates to the global functional outcome in young patients one year after mTBI. All patients with mTBI (Glasgow Coma Scale: 13-15) ≤24 years in the multi-center, prospective, observational Collaborative European NeuroTrauma Effectiveness Research in TBI (CENTER-TBI) study were included. Patient demographics and CT findings were assessed at admission, and the Glasgow Outcome Scale Extended (GOSE) was evaluated at 12 months follow-up. The association between a "positive CT" (at least one of the following: epidural hematoma, subdural hematoma, traumatic subarachnoid hemorrhage (tSAH), intraventricular hemorrhage, subdural collection mixed density, contusion, traumatic axonal injury) and functional outcome (GOSE) was assessed using multi-variable mixed ordinal and logistic regression models. A total of 462 patients with mTBI and initial brain CT from 46 study centers were included. The median age was 19 (17-22) years, and 322 (70%) were males. CT imaging showed a traumatic intracranial pathology in 171 patients (37%), most commonly tSAH (48%), contusions (40%), and epidural hematomas (37%). Patients with a positive CT scan were less likely to achieve a complete recovery 12 months post-injury. The presence of any CT abnormality was associated with both lower GOSE scores (odds ratio [OR]: 0.39 [0.24-0.63]) and incomplete recovery (GOSE <8; OR: 0.41 [0.25-0.68]), also when adjusted for demographical and clinical baseline factors. The presence of intracranial traumatic CT pathologies was predictive of outcome 12 months after mTBI in young patients, which might help to identify candidates for early follow-up and additional care.

Place, publisher, year, edition, pages
Mary Ann Liebert, 2023. Vol. 40, no 11-12, p. 1243-1254
Keywords [en]
CT findings, adolescents, children, intracranial lesions, mild TBI, outcome
National Category
Anesthesiology and Intensive Care
Identifiers
URN: urn:nbn:se:umu:diva-221575DOI: 10.1089/neu.2022.0055ISI: 000938494700001PubMedID: 36578216Scopus ID: 2-s2.0-85160968721OAI: oai:DiVA.org:umu-221575DiVA, id: diva2:1841000
Funder
EU, FP7, Seventh Framework Programme, 602150Available from: 2024-02-27 Created: 2024-02-27 Last updated: 2024-02-28Bibliographically approved

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Brorsson, CamillaKoskinen, Lars-Owe D.Sundström, Nina

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