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Time trends in herpesvirus seroepidemiology among Swedish adults
Umeå University, Faculty of Medicine, Department of Clinical Microbiology.ORCID iD: 0000-0001-9094-319x
Umeå University, Faculty of Medicine, Department of Clinical Microbiology.
Umeå University, Faculty of Medicine, Department of Clinical Microbiology.
Umeå University, Faculty of Medicine, Department of Odontology. (Aa-gruppen)ORCID iD: 0000-0002-8069-8263
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2024 (English)In: BMC Infectious Diseases, E-ISSN 1471-2334, Vol. 24, no 1, article id 273Article in journal (Refereed) Published
Abstract [en]

Background: Human herpesviruses are widespread among the human population. The infections often occurunnoticed, but severe disease as well as long-term sequelae are part of the symptom spectrum. The prevalence variesamong subpopulations and with time. The aim of this study was to describe the seroprevalence of ImmunoglobulinG against Herpes simplex 1, Herpes simplex 2, Epstein-Barr virus and Cytomegalovirus in the adult Swedish populationover a time period of several decades.

Methods: Serum samples (n = 892) from biobanks, originating from 30-year-old women, 50-year-old menand 50-year-old women sampled between 1975 and 2018, were analyzed for presence of anti-herpesvirus antibod-ies. Linear regression analysis was used to test for a correlation between birth year and seroprevalence. Multiple linearregression analysis was used to differentiate between other factors such as age and gender.

Results: Birth year correlated negatively with the prevalence of immunoglobulin G against Herpes simplex 1and Epstein-Barr virus (p = 0.004 and 0.033), and positively with Immunoglobulin G against Cytomegalovirus(p = 0.039). When participant categories were analyzed separately, birth year correlated negatively with the preva-lence of Immunoglobulin G against Herpes simplex 1 and Herpes simplex 2 (p = 0.032 and 0.028) in 30-year-old women,and with the prevalence of Immunoglobulin G against Cytomegalovirus in 50-year-old men (p = 0.011).

Conclusions: The prevalence of Immunoglobulin G against Herpes simplex 1, Herpes simplex 2 and Epstein-Barr virusdecreases in later birth cohorts. This indicates a trend of declining risk of getting infected with these viruses as a childand adolescen (9) (PDF) Time trends in herpesvirus seroepidemiology among Swedish adults. 

Place, publisher, year, edition, pages
Springer Nature, 2024. Vol. 24, no 1, article id 273
Keywords [en]
Herpes, Herpes simplex, Epstein-Barr virus, Cytomegalovirus, Seroprevalence, Epidemiology, Time trends, Immunoglobulin G
National Category
Public Health, Global Health, Social Medicine and Epidemiology Geriatrics Infectious Medicine
Research subject
Infectious Diseases; Geriatrics
Identifiers
URN: urn:nbn:se:umu:diva-221713DOI: 10.1186/s12879-024-09155-wPubMedID: 38431567Scopus ID: 2-s2.0-85186556771OAI: oai:DiVA.org:umu-221713DiVA, id: diva2:1842123
Funder
Region VästerbottenUmeå UniversityThe Dementia Association - The National Association for the Rights of the DementedAlzheimerfondenAvailable from: 2024-03-03 Created: 2024-03-03 Last updated: 2024-03-13Bibliographically approved

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Olsson, JanHonkala, EmmaHallmans, GöranLövheim, HugoElgh, Fredrik

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Olsson, JanHonkala, EmmaJohansson, AndersHallmans, GöranLövheim, HugoElgh, Fredrik
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BMC Infectious Diseases
Public Health, Global Health, Social Medicine and EpidemiologyGeriatricsInfectious Medicine

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