Umeå University's logo

umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Thromboembolic events, major bleeding and mortality in essential thrombocythaemia and polycythaemia vera: a matched nationwide population-based study
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine.ORCID iD: 0000-0002-9984-3520
Uppsala Clinical Research Centre Uppsala University, Uppsala, Sweden.
NU Hospital Group, Uddevalla, Sweden.
Umeå University, Faculty of Medicine, Department of Epidemiology and Global Health.ORCID iD: 0000-0001-6206-3099
Show others and affiliations
2024 (English)In: British Journal of Haematology, ISSN 0007-1048, E-ISSN 1365-2141Article in journal (Refereed) Epub ahead of print
Abstract [en]

Thromboembolic events and bleeding are known complications in essential thrombocythaemia (ET) and polycythaemia vera (PV). Using multiple Swedish health care registers, we assessed the rate of arterial and venous events, major bleeding, all-cause stroke and all-cause mortality in ET and PV compared to matched controls. For each patient with ET (n = 3141) and PV (n = 2604), five matched controls were randomly selected. In total, 327 and 405 arterial or venous events were seen in the group of ET and PV patients respectively. Compared to corresponding controls, the rate of venous thromboembolism, major bleeding and all-cause mortality per 100 treatment years was significantly increased among both ET (0.63, 0.79 and 3.70) and PV patients (0.94, 1.20 and 4.80). The PV patients also displayed a significantly higher rate of arterial events and all-cause stroke compared to controls. When dividing the cohort into age groups, we found a significantly higher rate of arterial and venous events in all age groups of PV patients, and the rate of all-cause mortality was significantly higher in both ET and PV patients in all ages above the age of 50. This study confirms that PV and ET are diseases truly marked by thromboembolic complications and bleeding.

Place, publisher, year, edition, pages
John Wiley & Sons, 2024.
Keywords [en]
essential thrombocythaemia, polycythaemia vera, thrombosis (venous), thrombosis - arterial
National Category
Hematology Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:umu:diva-221663DOI: 10.1111/bjh.19337PubMedID: 38351734Scopus ID: 2-s2.0-85185487280OAI: oai:DiVA.org:umu-221663DiVA, id: diva2:1842160
Funder
The Swedish Stroke AssociationVisare NorrAvailable from: 2024-03-04 Created: 2024-03-04 Last updated: 2024-03-04

Open Access in DiVA

fulltext(2483 kB)30 downloads
File information
File name FULLTEXT01.pdfFile size 2483 kBChecksum SHA-512
09a74bdd6b0fd0c22658a52a6ff1bec3dce7db72ed46dbf98fe9416c7c5cc42733f1e7e2eab0b704aff4cfe4b9f22769f95ef99b42761582baaab4db2db87cbc
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMedScopus

Authority records

Enblom-Larsson, AnneliHolmberg, HenrikLiljeholm, MariaSjälander, Anders

Search in DiVA

By author/editor
Enblom-Larsson, AnneliHolmberg, HenrikLiljeholm, MariaSjälander, Anders
By organisation
Department of Public Health and Clinical MedicineDepartment of Epidemiology and Global HealthOncology
In the same journal
British Journal of Haematology
HematologyCardiac and Cardiovascular Systems

Search outside of DiVA

GoogleGoogle Scholar
Total: 30 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 206 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf