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Longitudinal support for the correlative triad among aging, dopamine D2-like receptor loss, and memory decline
Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI). Umeå University, Faculty of Medicine, Department of Medical and Translational Biology.ORCID iD: 0000-0002-8603-9453
Aging Research Center, Karolinska Institutet & Stockholm University, Stockholm, Sweden.
Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI). Umeå University, Faculty of Medicine, Department of Radiation Sciences, Diagnostic Radiology. Umeå University, Faculty of Medicine, Department of Diagnostics and Intervention.ORCID iD: 0000-0002-4501-4735
Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI). Umeå University, Faculty of Science and Technology, Department of Applied Physics and Electronics. Umeå University, Faculty of Medicine, Department of Diagnostics and Intervention. Umeå University, Faculty of Medicine, Department of Radiation Sciences, Radiation Physics.ORCID iD: 0000-0001-6784-1945
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2024 (English)In: Neurobiology of Aging, ISSN 0197-4580, E-ISSN 1558-1497, Vol. 136, p. 125-132Article in journal (Refereed) Published
Abstract [en]

Dopamine decline is suggested to underlie aging-related cognitive decline, but longitudinal examinations of this link are currently missing. We analyzed 5-year longitudinal data for a sample of healthy, older adults (baseline: n = 181, age: 64–68 years; 5-year follow-up: n = 129) who underwent positron emission tomography with 11C-raclopride to assess dopamine D2-like receptor (DRD2) availability, magnetic resonance imaging to evaluate structural brain measures, and cognitive tests. Health, lifestyle, and genetic data were also collected. A data-driven approach (k-means cluster analysis) identified groups that differed maximally in DRD2 decline rates in age-sensitive brain regions. One group (n = 47) had DRD2 decline exclusively in the caudate and no cognitive decline. A second group (n = 72) had more wide-ranged DRD2 decline in putamen and nucleus accumbens and also in extrastriatal regions. The latter group showed significant 5-year working memory decline that correlated with putamen DRD2 decline, along with higher dementia and cardiovascular risk and a faster biological pace of aging. Taken together, for individuals with more extensive DRD2 decline, dopamine decline is associated with memory decline in aging.

Place, publisher, year, edition, pages
2024. Vol. 136, p. 125-132
Keywords [en]
11C-raclopride, Aging, Dopamine D2-like receptor, Longitudinal, Magnetic resonance imaging, Positron emission tomography, Working memory
National Category
Geriatrics
Identifiers
URN: urn:nbn:se:umu:diva-221540DOI: 10.1016/j.neurobiolaging.2024.02.001PubMedID: 38359585Scopus ID: 2-s2.0-85185304249OAI: oai:DiVA.org:umu-221540DiVA, id: diva2:1844971
Funder
Swedish Research Council, 421-2012-648Swedish Research Council, 2017-02217Swedish Research Council, 2022-01804Umeå UniversityKnut and Alice Wallenberg Foundation, 2015.0277Jonas and Christina af Jochnick FoundationAlzheimerfonden, AF-967710Riksbankens Jubileumsfond, P20-0779Region VästerbottenAvailable from: 2024-03-15 Created: 2024-03-15 Last updated: 2024-03-15Bibliographically approved

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Karalija, NinaJohansson, JarkkoWåhlin, AndersSalami, AlirezaAndersson, MicaelAxelsson, JanRiklund, KatrineNyberg, Lars

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Karalija, NinaJohansson, JarkkoWåhlin, AndersSalami, AlirezaAndersson, MicaelAxelsson, JanRiklund, KatrineNyberg, Lars
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Umeå Centre for Functional Brain Imaging (UFBI)Department of Medical and Translational BiologyDiagnostic RadiologyDepartment of Diagnostics and InterventionDepartment of Applied Physics and ElectronicsRadiation PhysicsWallenberg Centre for Molecular Medicine at Umeå University (WCMM)
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Neurobiology of Aging
Geriatrics

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