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Longitudinal change-change associations of cognition with cortical thickness and surface area
Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI). Umeå University, Faculty of Medicine, Department of Radiation Sciences, Diagnostic Radiology. Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB). Center for Lifespan Changes in Brain and Cognition, University of Oslo, Oslo, Norway. Department of Health, Education and Technology, Luleå University of Technology, Luleå, Sweden.ORCID iD: 0000-0002-3367-1746
Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI). Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB).ORCID iD: 0000-0003-4743-6365
Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI). Umeå University, Faculty of Social Sciences, Umeå School of Business and Economics (USBE), Statistics.ORCID iD: 0000-0003-1524-0851
2023 (English)In: Aging Brain, E-ISSN 2589-9589, Vol. 3, article id 100070Article in journal (Refereed) Published
Abstract [en]

Age-related changes in cortical volumes are well established but relatively few studies probed its constituents, surface area (SA) and thickness (TH). Here we analyzed 10-year, 3-waves longitudinal data from a large sample of healthy individuals (baseline age = 55- 80). The findings showed marked age-related changes of SA in frontal, temporal, and parietal association cortices, and Bivariate Latent Change Score models revealed significant SAassociations with changes in speed of processing in both the 5- and 10-year models. The corresponding results for TH revealed a late onset of thinning and significant associations with reduced cognition in the 10-year model only. Taken together, our findings suggest that cortical surface area shrinks and impacts information-processing capacity gradually in aging, whereas cortical thinning only manifests and impacts fluid cognition in advanced aging. 

Place, publisher, year, edition, pages
Elsevier, 2023. Vol. 3, article id 100070
Keywords [en]
Cortex, Thickness, Surface area, Cognition, Speed
National Category
Neurosciences Neurology
Identifiers
URN: urn:nbn:se:umu:diva-222727DOI: 10.1016/j.nbas.2023.100070ISI: 001133947400001PubMedID: 37408792OAI: oai:DiVA.org:umu-222727DiVA, id: diva2:1847125
Funder
Knut and Alice Wallenberg FoundationSwedish Research Council, 2018-05973Available from: 2024-03-26 Created: 2024-03-26 Last updated: 2024-03-27Bibliographically approved

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Nyberg, LarsAndersson, MicaelLundquist, Anders

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Umeå Centre for Functional Brain Imaging (UFBI)Diagnostic RadiologyDepartment of Integrative Medical Biology (IMB)Statistics
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