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ABO blood groups, RhD factor and their association with subclinical atherosclerosis assessed by carotid ultrasonography
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Clinical chemistry.ORCID iD: 0000-0001-7491-2414
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Clinical chemistry. Department of Research and Development, Region Kronoberg, Växjö, Sweden.ORCID iD: 0000-0003-2844-1310
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Clinical chemistry.ORCID iD: 0000-0001-8690-2117
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Section of Medicine.
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2024 (English)In: Journal of Clinical Medicine, E-ISSN 2077-0383, Vol. 13, no 5, article id 1333Article in journal (Refereed) Published
Abstract [en]

Background: The ABO blood group system has previously been associated with cardiovascular disease (CVD), where non-O blood group individuals have shown an increased risk. Studies assessing early atherosclerotic disease while also including RhD are few. We aimed to determine whether the ABO and RhD blood groups are associated with subclinical atherosclerosis in a healthy population.

Methods: We included 3532 participants from the VIPVIZA trial with available carotid ultrasonography results to assess subclinical disease. Information about blood groups was obtained from the SCANDAT-3 database, where 85% of VIPVIZA participants were registered.

Results: RhD− individuals aged 40 years showed increased carotid intima–media thickness (B 1.09 CI 95% 1.03; 1.14) compared to RhD+ individuals. For ABO, there were no differences in ultrasonography results when assessing the whole study population. However, 60-year-old individuals with heredity for CVD and a non-O blood group had decreased odds for carotid plaques (OR 0.54 CI 95% 0.33; 0.88).

Conclusions: RhD blood group is associated with subclinical atherosclerosis in younger individuals, indicating a role as a mediator in the atherosclerotic process. In addition, a non-O blood group was associated with decreased subclinical atherosclerosis in individuals aged 60 and with heredity (corresponding to the group with the highest atherosclerotic burden).

Place, publisher, year, edition, pages
MDPI, 2024. Vol. 13, no 5, article id 1333
Keywords [en]
ABO blood group system, atherosclerosis, cardiovascular prevention, carotid intima–media thickness, carotid plaques, RhD factor
National Category
Cardiac and Cardiovascular Systems Hematology
Identifiers
URN: urn:nbn:se:umu:diva-222584DOI: 10.3390/jcm13051333ISI: 001182882700001Scopus ID: 2-s2.0-85187443119OAI: oai:DiVA.org:umu-222584DiVA, id: diva2:1849521
Funder
Visare Norr, Dnr 981146Region Västerbotten, ALFVLL-298001Region Västerbotten, AALFVLL-643391Swedish Research Council, 521-2013-2708Swedish Research Council, 2016-01891Swedish Heart Lung Foundation, 20150369Swedish Heart Lung Foundation, 20170481Available from: 2024-04-08 Created: 2024-04-08 Last updated: 2024-04-08Bibliographically approved

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Mickelsson, MalinEkblom, KimStefansson, KristinaLiv, PerNyman, EmmaSjälander, AndersNäslund, UlfHultdin, Johan

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