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Bacterial symbionts in oral niche use type VI secretion nanomachinery for fitness increase against pathobionts
Umeå University, Faculty of Medicine, Department of Odontology.ORCID iD: 0000-0002-7948-9464
Division of Oral Health and Periodontology, Department of Dental Medicine, Karolinska Institutet, Huddinge, Stockholm, Sweden.
Sapporo Medical University, Sapporo, Hakkaido, Japan.
Functional Genomics Center Zurich, ETH Zurich and University of Zurich, Switzerland; Swiss Institute of Bioinformatics (SIB) Quartier Sorge-Batiment Amphipole, Lausanne, Switzerland.
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2024 (English)In: iScience, ISSN 2589-0042, article id 109650Article in journal (Refereed) Published
Abstract [en]

Microbial ecosystems experience spatial and nutrient restrictions, leading to the coevolution of cooperation and competition among cohabiting species. To increase their fitness for survival, bacteria exploit machinery to antagonizing rival species upon close contact. As such, the bacterial type VI secretion system (T6SS) nanomachinery, typically expressed by pathobionts, can transport proteins directly into eukaryotic or prokaryotic cells, consequently killing cohabiting competitors. Here we demonstrate first time that oral symbiont Aggregatibacter aphrophilus possesses a T6SS and can eliminate its close relative oral pathobiont Aggregatibacter actinomycetemcomitans using its T6SS. These findings bring newer the anti-bacterial prospects of symbionts against cohabiting pathobionts while introducing presence of an active T6SS in the oral cavity.

Place, publisher, year, edition, pages
Elsevier, 2024. article id 109650
Keywords [en]
Pathobiont, aggregatibacter species, Type VI secretion system
National Category
Infectious Medicine Dentistry
Research subject
Microbiology
Identifiers
URN: urn:nbn:se:umu:diva-223048DOI: 10.1016/j.isci.2024.109650Scopus ID: 2-s2.0-85190136052OAI: oai:DiVA.org:umu-223048DiVA, id: diva2:1850204
Funder
Swedish Research Council, 2022-010Available from: 2024-04-09 Created: 2024-04-09 Last updated: 2024-04-22Bibliographically approved

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Oscarsson, JanAung, Kyaw MinLindholm, MarkJohansson, AndersWai, Sun Nyunt

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Oscarsson, JanAung, Kyaw MinLindholm, MarkJohansson, AndersWai, Sun Nyunt
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Department of OdontologyMolecular Infection Medicine Sweden (MIMS)Department of Molecular Biology (Faculty of Medicine)Umeå Centre for Microbial Research (UCMR)
Infectious MedicineDentistry

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CiteExportLink to record
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Citation style
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