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Discordant gene expression in subcutaneous adipose and skeletal muscle tissues in response to exercise training
Umeå University, Faculty of Medicine, Department of Community Medicine and Rehabilitation, Section of Sports Medicine.ORCID iD: 0000-0003-4972-4416
Department of Laboratory Medicine, Division of Clinical Physiology, Karolinska Institutet, and Unit of Clinical Physiology, Karolinska University Hospital, Stockholm, Sweden.ORCID iD: 0000-0001-5778-9928
Department of Medical Sciences, Clinical Chemistry, Uppsala University, Uppsala, Sweden.ORCID iD: 0000-0003-0214-596X
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences.ORCID iD: 0000-0001-6067-518X
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2024 (English)In: Physiological Reports, E-ISSN 2051-817X, Vol. 12, no 7, article id e15995Article in journal (Refereed) Published
Abstract [en]

Exercise has different effects on different tissues in the body, the sum of which may determine the response to exercise and the health benefits. In the present study, we aimed to investigate whether physical training regulates transcriptional network communites common to both skeletal muscle (SM) and subcutaneous adipose tissue (SAT). Eight such shared transcriptional communities were found in both tissues. Eighteen young overweight adults voluntarily participated in 7 weeks of combined strength and endurance training (five training sessions per week). Biopsies were taken from SM and SAT before and after training. Five of the network communities were regulated by training in SM but showed no change in SAT. One community involved in insulin- AMPK signaling and glucose utilization was upregulated in SM but downregulated in SAT. This diverging exercise regulation was confirmed in two independent studies and was also associated with BMI and diabetes in an independent cohort. Thus, the current finding is consistent with the differential responses of different tissues and suggests that body composition may influence the observed individual whole-body metabolic response to exercise training and help explain the observed attenuated whole-body insulin sensitivity after exercise training, even if it has significant effects on the exercising muscle.

Place, publisher, year, edition, pages
John Wiley & Sons, 2024. Vol. 12, no 7, article id e15995
Keywords [en]
adipose tissue, GTEx, mRNA-sequencing, obesity, skeletal muscle
National Category
Sport and Fitness Sciences Physiology
Research subject
molecular cell biology
Identifiers
URN: urn:nbn:se:umu:diva-223435DOI: 10.14814/phy2.15995ISI: 001194508100001PubMedID: 38561245Scopus ID: 2-s2.0-85189566155OAI: oai:DiVA.org:umu-223435DiVA, id: diva2:1851827
Funder
Swedish Heart Lung Foundation, 20220725Available from: 2024-04-16 Created: 2024-04-16 Last updated: 2024-04-16Bibliographically approved

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Svensson, Michael B.Hellsten, David

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