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Factors most strongly associated with breathlessness in a population aged 50–64 years
Lund University, Faculty of Medicine, Department of Clinical Sciences Lund, Respiratory Medicine, Allergology and Palliative Medicine, Lund, Sweden.
Lund University, Faculty of Science, Centre for Environmental and Climate Science, Lund, Sweden.
Lund University, Faculty of Medicine, Department of Clinical Sciences Lund, Respiratory Medicine, Allergology and Palliative Medicine, Lund, Sweden.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine.ORCID iD: 0000-0002-2452-7347
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2024 (English)In: ERJ Open Research, E-ISSN 2312-0541, Vol. 10, no 2, article id 00582-2023Article in journal (Refereed) Published
Abstract [en]

Background: Breathlessness is a troublesome and prevalent symptom in the population, but knowledge of related factors is scarce. The aim of this study was to identify the factors most strongly associated with breathlessness in the general population and to describe the shapes of the associations between the main factors and breathlessness.

Methods: A cross-sectional analysis was carried out of the multicentre population-based Swedish CArdioPulmonary bioImage Study (SCAPIS) of adults aged 50 to 64 years. Breathlessness was defined as a modified Medical Research Council breathlessness rating ⩾2. The machine learning algorithm extreme gradient boosting (XGBoost) was used to classify participants as either breathless or nonbreathless using 449 factors, including physiological measurements, blood samples, computed tomography cardiac and lung measurements, lifestyle, health conditions and socioeconomics. The strength of the associations between the factors and breathlessness were measured by SHapley Additive exPlanations (SHAP), with higher scores reflecting stronger associations.

Results :A total of 28 730 participants (52% women) were included in the study. The strongest associated factors for breathlessness were (in order of magnitude): body mass index (SHAP score 0.39), forced expiratory volume in 1 s (0.32), physical activity measured by accelerometery (0.27), sleep apnoea (0.22), diffusing lung capacity for carbon monoxide (0.21), self-reported physical activity (0.17), chest pain when hurrying (0.17), high-sensitivity C-reactive protein (0.17), recent weight change (0.14) and cough (0.13).

Conclusion: This large population-based study of men and women aged 50–64 years identified the main factors related to breathlessness that may be prevented or amenable to public health interventions.

Place, publisher, year, edition, pages
European Respiratory Society, 2024. Vol. 10, no 2, article id 00582-2023
National Category
Respiratory Medicine and Allergy
Identifiers
URN: urn:nbn:se:umu:diva-223074DOI: 10.1183/23120541.00582-2023ISI: 001193980300005PubMedID: 38529345Scopus ID: 2-s2.0-85189107812OAI: oai:DiVA.org:umu-223074DiVA, id: diva2:1852392
Funder
Swedish Heart Lung FoundationKnut and Alice Wallenberg FoundationSwedish Research CouncilVinnovaUniversity of GothenburgKarolinska InstituteRegion StockholmLinköpings universitetLund UniversityUmeå UniversityUppsala UniversitySwedish Research Council, 2019-02081Available from: 2024-04-18 Created: 2024-04-18 Last updated: 2024-04-18Bibliographically approved

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Blomberg, Anders

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