Umeå University's logo

umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Dopamine D1-receptor organization contributes to functional brain architecture
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB). Umeå University, Faculty of Medicine, Wallenberg Centre for Molecular Medicine at Umeå University (WCMM). Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI).
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB). Umeå University, Faculty of Medicine, Wallenberg Centre for Molecular Medicine at Umeå University (WCMM). Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI).ORCID iD: 0000-0002-4501-4735
Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI). Aging Research Center, Karolinska Institutet, Sweden; Stockholm University, Stockholm, Sweden.ORCID iD: 0000-0003-4157-1638
Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI). Umeå University, Faculty of Medicine, Department of Radiation Sciences. Max-Planck-Institut für Sozialrecht und Sozialpolitik, Munich, Germany.ORCID iD: 0000-0002-5389-1578
Show others and affiliations
2024 (English)In: Journal of Neuroscience, ISSN 0270-6474, E-ISSN 1529-2401, Vol. 44, no 11, article id e0621232024Article in journal (Refereed) Published
Abstract [en]

Recent work has recognized a gradient-like organization in cortical function, spanning from primary sensory to transmodal cortices. It has been suggested that this axis is aligned with regional differences in neurotransmitter expression. Given the abundance of dopamine D1-receptors (D1DR), and its importance for modulation and neural gain, we tested the hypothesis that D1DR organization is aligned with functional architecture, and that inter-regional relationships in D1DR co-expression modulate functional cross talk. Using the world's largest dopamine D1DR-PET and MRI database (N = 180%, 50% female), we demonstrate that D1DR organization follows a unimodal–transmodal hierarchy, expressing a high spatial correspondence to the principal gradient of functional connectivity. We also demonstrate that individual differences in D1DR density between unimodal and transmodal regions are associated with functional differentiation of the apices in the cortical hierarchy. Finally, we show that spatial co-expression of D1DR primarily modulates couplings within, but not between, functional networks. Together, our results show that D1DR co-expression provides a biomolecular layer to the functional organization of the brain.

Place, publisher, year, edition, pages
Society for Neuroscience , 2024. Vol. 44, no 11, article id e0621232024
Keywords [en]
architecture, dopamine, functional connectivity, gradients, organization
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:umu:diva-222641DOI: 10.1523/JNEUROSCI.0621-23.2024PubMedID: 38302439Scopus ID: 2-s2.0-85187783583OAI: oai:DiVA.org:umu-222641DiVA, id: diva2:1852825
Available from: 2024-04-19 Created: 2024-04-19 Last updated: 2024-04-19Bibliographically approved

Open Access in DiVA

fulltext(3629 kB)574 downloads
File information
File name FULLTEXT01.pdfFile size 3629 kBChecksum SHA-512
1cad6d14db723a47a71e75633d0f28bc031576b75d8e587060cf98d5c43306f312999c9c9ea396a22a353e80879efe4244bc70cddf893e7d799f50092df9d4a4
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMedScopus

Authority records

Pedersen, RobinJohansson, JarkkoNordin, KristinRieckmann, AnnaWåhlin, AndersNyberg, LarsSalami, Alireza

Search in DiVA

By author/editor
Pedersen, RobinJohansson, JarkkoNordin, KristinRieckmann, AnnaWåhlin, AndersNyberg, LarsSalami, Alireza
By organisation
Department of Integrative Medical Biology (IMB)Wallenberg Centre for Molecular Medicine at Umeå University (WCMM)Umeå Centre for Functional Brain Imaging (UFBI)Department of Radiation Sciences
In the same journal
Journal of Neuroscience
Neurosciences

Search outside of DiVA

GoogleGoogle Scholar
Total: 574 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 763 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf