Umeå University's logo

umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Illuminating the complete ß-cell mass of the human pancreas - signifying a new view on the islets of Langerhans
Umeå University, Faculty of Medicine, Department of Medical and Translational Biology.
Umeå University, Faculty of Medicine, Department of Medical and Translational Biology.ORCID iD: 0000-0003-0232-1812
Umeå University, Faculty of Medicine, Department of Medical and Translational Biology.ORCID iD: 0000-0002-0712-8256
Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Show others and affiliations
2024 (English)In: Nature Communications, E-ISSN 2041-1723, Vol. 15, no 1, article id 3318Article in journal (Refereed) Published
Abstract [en]

Pancreatic islets of Langerhans play a pivotal role in regulating blood glucose homeostasis, but critical information regarding their mass, distribution and composition is lacking within a whole organ context. Here, we apply a 3D imaging pipeline to generate a complete account of the insulin-producing islets throughout the human pancreas at a microscopic resolution and within a maintained spatial 3D context. These data show that human islets are far more heterogenous than previously accounted for with regards to their size distribution and cellular make up. By deep tissue 3D imaging, this in-depth study demonstrates that 50% of the human insulin-expressing islets are virtually devoid of glucagon-producing α-cells, an observation with significant implications for both experimental and clinical research.

Place, publisher, year, edition, pages
Springer Nature, 2024. Vol. 15, no 1, article id 3318
National Category
Endocrinology and Diabetes Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:umu:diva-223844DOI: 10.1038/s41467-024-47686-7ISI: 001204844700001PubMedID: 38632302Scopus ID: 2-s2.0-85190704494OAI: oai:DiVA.org:umu-223844DiVA, id: diva2:1855072
Funder
The Kempe Foundations, SMK-1455Swedish Research Council, 2017- 01307Swedish Research Council, 2023-02221Swedish Child Diabetes FoundationNovo Nordisk Foundation, NNF21OC0069771Novo Nordisk Foundation, NNF21OC0084520Novo Nordisk Foundation, NNF20OC0063600Insamlingsstiftelsen Diabetes Wellness, PG21-6566Ernfors Foundation, 2023Diabetesfonden, DIA2021-59Available from: 2024-04-29 Created: 2024-04-29 Last updated: 2024-04-29Bibliographically approved

Open Access in DiVA

fulltext(5485 kB)32 downloads
File information
File name FULLTEXT01.pdfFile size 5485 kBChecksum SHA-512
2f18aede799ab28c443d02219412e99d4092942ac3051f32ea1a927c00321b7939f3fa8b5c60c85a224eb7159cecb3de1db7f21c93360f24206968f16f8cc4fc
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMedScopus

Authority records

Lehrstrand, JoakimDavies, Wayne I. L.Hahn, MaxAlanentalo, TomasAhlgren, Ulf

Search in DiVA

By author/editor
Lehrstrand, JoakimDavies, Wayne I. L.Hahn, MaxAlanentalo, TomasAhlgren, Ulf
By organisation
Department of Medical and Translational Biology
In the same journal
Nature Communications
Endocrinology and DiabetesCell and Molecular Biology

Search outside of DiVA

GoogleGoogle Scholar
Total: 32 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 210 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf