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Quantitative proteomics for translational pharmacology and precision medicine: state of the art and future outlook
Department of Pharmaceutical Sciences, Washington State University, WA, Spokane, United States; College of Pharmacy and Pharmaceutical Sciences, Washington State University, WA, Spokane, United States.
Centre for Applied Pharmacokinetic Research, University of Manchester, Manchester, United Kingdom.
Umeå University, Faculty of Science and Technology, Department of Plant Physiology.ORCID iD: 0000-0002-2810-7518
Centre for Applied Pharmacokinetic Research, University of Manchester, Manchester, United Kingdom; Certara UK, Sheffield, United Kingdom.
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2024 (English)In: Drug Metabolism And Disposition, ISSN 0090-9556, E-ISSN 1521-009X, Vol. 52, no 7Article in journal (Refereed) Epub ahead of print
Abstract [en]

Over the past 20 years, quantitative proteomics has contributed a wealth of protein expression data, which are currently used for a variety of systems pharmacology applications, as a complement or a surrogate for activity of the corresponding proteins. A symposium at the 25th North American ISSX meeting, in Boston, in September 2023, was held to explore current and emerging applications of quantitative proteomics in translational pharmacology and strategies for improved integration into model-informed drug development based on practical experience of each of the presenters. A summary of the talks and discussions is presented in this perspective alongside future outlooks that were outlined for future meetings.

Place, publisher, year, edition, pages
2024. Vol. 52, no 7
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Pharmacology and Toxicology
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URN: urn:nbn:se:umu:diva-226964DOI: 10.1124/dmd.124.001600PubMedID: 38821856Scopus ID: 2-s2.0-85196077908OAI: oai:DiVA.org:umu-226964DiVA, id: diva2:1876331
Available from: 2024-06-24 Created: 2024-06-24 Last updated: 2024-08-01

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Wegler, Christine

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