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Clamping Pol ε to the leading strand
Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics.
Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics.ORCID iD: 0000-0002-8526-6224
2024 (English)In: Nature Structural & Molecular Biology, ISSN 1545-9993, E-ISSN 1545-9985, Vol. 31, no 11, p. 1644-1645Article in journal (Refereed) Published
Abstract [en]

Two recent studies provide structural insights into how human DNA polymerase ε (Pol ε) interacts with PCNA to form a processive holoenzyme on the leading strand. A series of cryo-EM images offer structural information on the proofreading process, showing how DNA is transferred between the polymerase and exonuclease sites in human Pol ε.

Place, publisher, year, edition, pages
Springer Nature, 2024. Vol. 31, no 11, p. 1644-1645
National Category
Biochemistry Molecular Biology Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:umu:diva-231301DOI: 10.1038/s41594-024-01416-1ISI: 001338055500001PubMedID: 39438714Scopus ID: 2-s2.0-85207035793OAI: oai:DiVA.org:umu-231301DiVA, id: diva2:1911235
Funder
Swedish Research Council, 2021-01104Swedish Cancer Society, 23 2999 Pj 01 HAvailable from: 2024-11-07 Created: 2024-11-07 Last updated: 2025-02-20Bibliographically approved

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Singh, NoopurJohansson, Erik

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