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Physical activity habits and incident first-ever stroke in middle-aged adults: a prospective cohort study
Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden.
Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Family Medicine.ORCID iD: 0000-0002-1617-6102
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Section of Medicine.ORCID iD: 0000-0001-9225-1306
2025 (English)In: Journal of Physical Activity and Health, ISSN 1543-3080, E-ISSN 1543-5474, Vol. 22, no 5, p. 575-581Article in journal (Refereed) Published
Abstract [en]

Background: Lifestyle affects the risk of cardiovascular events such as myocardial infarction and stroke. Several lifestyle factors, such as physical activity (PA), are modifiable, and in this study, we examined the association between leisure-time PA habits and the risk of a first-ever stroke.

Methods: This prospective study included residents in Västerbotten, Sweden, who participated in the Västerbotten Intervention Programme at 40, 50, and 60 years of age. Altogether, 31,855 individuals (50.5% women, mean age: 42.6 [6.9] y at baseline) participated between 1989 and 2016. Leisure-time PA was categorized as irregular (never/now and then) or regular (once a week/2 or 3 times a week/more than 3 times a week). Changes in PA were compared between examinations (10 y apart). Cases of stroke were validated according to World Health Organization MONICA (Monitoring Trends and Determinants of Cardiovascular Disease) criteria. The risk related to changes in leisure-time PA was estimated using a multivariable Cox regression model.

Results: During an average follow-up of 9.8 years (4.4), 609 incident first-ever stroke cases occurred (1.9%). A multivariable model showed that, compared with individuals with irregular PA at both examinations, those reporting regular PA over time had a lower risk of stroke (hazard ratio: 0.78, 95% CI, 0.61–0.99).

Conclusion: Middle-aged adults who maintained regular PA during their leisure time over 10 years had a lower risk of a first-ever stroke. This association is probably partly mediated by lower body mass index and a reduced risk of hypertension and diabetes.

Place, publisher, year, edition, pages
Human Kinetics, 2025. Vol. 22, no 5, p. 575-581
Keywords [en]
epidemiology, exercise, healthy lifestyle, incidence
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:umu:diva-238109DOI: 10.1123/jpah.2024-0411ISI: 001413947400001PubMedID: 39884283Scopus ID: 2-s2.0-105002779726OAI: oai:DiVA.org:umu-238109DiVA, id: diva2:1956116
Funder
The Swedish Stroke AssociationAvailable from: 2025-05-05 Created: 2025-05-05 Last updated: 2025-05-05Bibliographically approved

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Wennberg, PatrikSöderberg, Stefan

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