The occupants influence the building's energy-efficient renovation through energy-related behaviors. The renovation, on the other hand, influences the occupant's behaviors due to the created new indoor environments. However, the consistent understanding and conclusive findings regarding how occupants and renovations influence each other are still lacking. These knowledge gaps result in an inaccurate or oversimplified understanding of the role that occupants can play in energy conservation. An experimental laboratory was established at Umeå University named Intelligent Human-Buildings Interaction (IHBI) lab to investigate the relationship between occupant behaviors and energy-efficient renovations. It integrates virtual technology (virtual reality) and physical technology (climate chamber). The occupants in the laboratory can interact with the renovated buildings virtually; synchronously, they physically perceive the buildings with renovation. Virtual reality increases the virtual immersion, while a climate chamber ensures physical perception. This experimental approach is applied to an office building looking for renovation at Umeå University. It was found that renovation clearly impacts personal heater use and door control but does not impact clothing behavior. The reduction of personal heater use leads to additional energy reduction contributed by occupant behaviors. This laboratory experimental approach provides insights regarding the influences between occupants and renovations, which are essential to engage the public such as general residents in achieving occupant-centric building energy-efficient transitions.