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ACGM: attribute-centric graph modeling network for concurrent missing tabular data imputation and COVID-19 prognosis
College of Computer Science and Software Engineering, Shenzhen University, Shenzhen, China.
Department of Electrical Engineering, City University of Hong Kong, Hong Kong.
School of Electronics and Information Engineering, Wuyi University, Jiangmen, China.
Unit of Artificial Intelligence and Computer Systems, Department of Engineering, Università Campus Bio-Medico di Roma, Roma, Italy.
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2026 (English)In: IEEE journal of biomedical and health informatics, ISSN 2168-2194, E-ISSN 2168-2208, Vol. 30, no 4, p. 3307-3320Article in journal (Refereed) Published
Abstract [en]

COVID-19 prognosis using clinical tabular data faces significant challenges due to missing values and class imbalance issues. Existing methods often overlook the complex high-order interrelationship among clinicalattributes and struggle with training stability on imbalanced datasets. We propose ACGM, an attribute-centric graph modeling network that simultaneously addresses missing data imputation and COVID-19 prognosis. ACGM consists of three key modules: an attributes preprocessing module (APM) for coarse-grained imputation initialization, a graph-enhanced attributes imputation module (GEAIM) that models high-order inter-attribute relationships through graph structures, and a graph-enhanced disease prognosis module (GEDPM) that leverages these complex attribute interactions for final prediction. GEAIM and GEDPM employ a mean-teacher strategy with attributes graph matching to preserve high-order relationships, enhance training stability, and maintain structural integrity of attribute interactions. Extensive experiments are conducted on four public COVID-19 tabular datasets, demonstrating the superiority of our ACGM over existing methods. Through comprehensive interpretability analysis, we identify that attributes such as LDH, Difficulty In Breathing, and SaO2 significantly impact COVID-19 prognosis, aligning well with clinical insights and radiologist assessments.

Place, publisher, year, edition, pages
IEEE, 2026. Vol. 30, no 4, p. 3307-3320
Keywords [en]
attribute-centric, COVID-19 prognosis, graph, missing tabular data imputation
National Category
Computer Sciences
Identifiers
URN: urn:nbn:se:umu:diva-252258DOI: 10.1109/JBHI.2025.3618935PubMedID: 41056179Scopus ID: 2-s2.0-105018503443OAI: oai:DiVA.org:umu-252258DiVA, id: diva2:2054141
Available from: 2026-04-20 Created: 2026-04-20 Last updated: 2026-04-20Bibliographically approved

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Soda, Paolo

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