3D CT-to-PET translation via latent-guided contrastive alignment and brownian bridge diffusion
2026 (English)In: ACM-BCB 2026 - 17th ACM International Conference on Bioinformatics, Computational Biology and Health Informatics, ACM Digital Library, 2026, article id 128Conference paper, Published paper (Refereed)
Abstract [en]
Computed Tomography (CT) and Positron Emission Tomography (PET) provide complementary anatomical and metabolic information essential for oncology assessment; however, PET imaging remains constrained by radiation exposure, acquisition cost, and limited accessibility. This work proposes a 3D CT-to-PET translation framework that integrates contrastive latent representation learning within a variational autoencoder (VAE) and Brownian Bridge diffusion to effectively bridge structural and functional modality differences. Evaluated on 1,014 paired PET/CT volumes across five anatomical regions-brain, lung, liver, kidney, and stomach-the proposed approach demonstrates improved synthetic PET signal fidelity and reliable lesion representation while maintaining efficient diffusion inference, supporting diagnostically meaningful virtual PET imaging applications.
Place, publisher, year, edition, pages
ACM Digital Library, 2026. article id 128
Keywords [en]
Brownian Bridge diffusion, contrastive learning, CT-to-PET translation, latent diffusion, medical imaging., variational autoencoder
National Category
Radiology and Medical Imaging Bioinformatics (Computational Biology)
Identifiers
URN: urn:nbn:se:umu:diva-257853DOI: 10.1145/3807503.3816794Scopus ID: 2-s2.0-105046619296ISBN: 9798400726538 (electronic)OAI: oai:DiVA.org:umu-257853DiVA, id: diva2:2096584
Conference
17th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics, ACM-BCB 2026, Rende, Italy 30 June - 3 July 2026.
2026-08-312026-08-312026-08-31Bibliographically approved