In the present article, we reflect on some didactic challenges and possibilities that emerge when teaching in interdisciplinary settings. We argue that teaching in interdisciplinary studies rests on movements between different understandings, and that it gives ample opportunities for beneficial learning processes. This does not only apply to interdisciplinary studies. The metaphor of taking a journey can be used to illustrate thelearning process and the dimension of personal change associated with moving between different understandings and discourses of knowledge. Some of the questions we raise in this article are: In what ways can differing disciplinary backgrounds be of help or create a hindrance? What are the specificdidactic challenges one faces? What happens to one’s understanding of one’s own subject afterhaving been confronted with something new and different?