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Blood transfusions are not a risk factor for necrotizing enterocolitis in extremely preterm infants
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Paediatrics.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Paediatrics.ORCID iD: 0000-0002-7511-7217
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Paediatrics.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Paediatrics.
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2014 (English)In: Archives of Disease in Childhood, ISSN 0003-9888, E-ISSN 1468-2044, Vol. 99, no Suppl 2, p. A177-A177, article id PS-183Article in journal, Meeting abstract (Refereed) Published
Abstract [en]

Background:  Transfusion practices are highly variable between hospitals and previous studies have suggested that blood transfusions may increase the risk of necrotizing enterocolitis (NEC).

Aim: To explore the association between blood transfusions and incidence of NEC in extremely preterm infants.

Methods: We used data from a Swedish population-based study including extremely preterm infants (<27 weeks) born between 2004–2007, (n = 602). All data on blood transfusions and haemoglobin (Hb) concentrations up to 28 days of age was collected for survivors. We performed a nested case-control study where two controls were chosen for each case of NEC (n = 21).

Results: During the first 28 days of life, infants received a median (25th-75th percentile) of 6 (3–9) blood transfusions resulting in 75 (44–120) ml/kg of blood. Predictors for receiving a higher volume of blood transfusions were days on respiratory support (R = 0.345, p < 0.001), hospital (R = 0.339, p < 0.001), low birth weight (R = -0.236, p < 0.001) and total steroid dose (R = 0.209, p < 0.001). Hb was not a significant predictor.

Overall NEC incidence was 5.8%. There was no significant difference between NEC cases and controls in number of blood transfusions (p = 0.420), volume of blood transfused from birth to NEC diagnosis (p = 0.274), or during the 48 h preceding NEC diagnosis (p = 0.459).

Conclusions: Blood transfusions were given liberally in Sweden compared to other studied populations. Morbidity related variables, especially those related to respiratory illness, were significant predictors of blood transfusion. NEC incidence was comparable with other populations but no significant association was found between blood transfusions and NEC among these extremely preterm infants.

Place, publisher, year, edition, pages
BMJ Publishing Group Ltd, 2014. Vol. 99, no Suppl 2, p. A177-A177, article id PS-183
National Category
Medical and Health Sciences
Research subject
Pediatrics
Identifiers
URN: urn:nbn:se:umu:diva-104304DOI: 10.1136/archdischild-2014-307384.480OAI: oai:DiVA.org:umu-104304DiVA, id: diva2:818900
Conference
The 5th Congress of European Academy of Paediatric Societies (EAPS), Barcelona, Spain, October 17-21, 2014
Available from: 2015-06-09 Created: 2015-06-09 Last updated: 2021-09-03Bibliographically approved

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Challis, PontusSpäth, CorneliaStoltz Sjöström, ElisabethDomellöf, Magnus

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