Umeå universitets logga

umu.sePublikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Blood transfusions are not a risk factor for necrotizing enterocolitis in extremely preterm infants
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Pediatrik.
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Pediatrik.ORCID-id: 0000-0002-7511-7217
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Pediatrik.
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Pediatrik.ORCID-id: 0000-0002-4649-0653
Visa övriga samt affilieringar
2014 (Engelska)Ingår i: Archives of Disease in Childhood, ISSN 0003-9888, E-ISSN 1468-2044, Vol. 99, nr Suppl 2, s. A177-A177, artikel-id PS-183Artikel i tidskrift, Meeting abstract (Refereegranskat) Published
Abstract [en]

Background:  Transfusion practices are highly variable between hospitals and previous studies have suggested that blood transfusions may increase the risk of necrotizing enterocolitis (NEC).

Aim: To explore the association between blood transfusions and incidence of NEC in extremely preterm infants.

Methods: We used data from a Swedish population-based study including extremely preterm infants (<27 weeks) born between 2004–2007, (n = 602). All data on blood transfusions and haemoglobin (Hb) concentrations up to 28 days of age was collected for survivors. We performed a nested case-control study where two controls were chosen for each case of NEC (n = 21).

Results: During the first 28 days of life, infants received a median (25th-75th percentile) of 6 (3–9) blood transfusions resulting in 75 (44–120) ml/kg of blood. Predictors for receiving a higher volume of blood transfusions were days on respiratory support (R = 0.345, p < 0.001), hospital (R = 0.339, p < 0.001), low birth weight (R = -0.236, p < 0.001) and total steroid dose (R = 0.209, p < 0.001). Hb was not a significant predictor.

Overall NEC incidence was 5.8%. There was no significant difference between NEC cases and controls in number of blood transfusions (p = 0.420), volume of blood transfused from birth to NEC diagnosis (p = 0.274), or during the 48 h preceding NEC diagnosis (p = 0.459).

Conclusions: Blood transfusions were given liberally in Sweden compared to other studied populations. Morbidity related variables, especially those related to respiratory illness, were significant predictors of blood transfusion. NEC incidence was comparable with other populations but no significant association was found between blood transfusions and NEC among these extremely preterm infants.

Ort, förlag, år, upplaga, sidor
BMJ Publishing Group Ltd, 2014. Vol. 99, nr Suppl 2, s. A177-A177, artikel-id PS-183
Nationell ämneskategori
Medicin och hälsovetenskap
Forskningsämne
pediatrik
Identifikatorer
URN: urn:nbn:se:umu:diva-104304DOI: 10.1136/archdischild-2014-307384.480OAI: oai:DiVA.org:umu-104304DiVA, id: diva2:818900
Konferens
The 5th Congress of European Academy of Paediatric Societies (EAPS), Barcelona, Spain, October 17-21, 2014
Tillgänglig från: 2015-06-09 Skapad: 2015-06-09 Senast uppdaterad: 2024-07-02Bibliografiskt granskad

Open Access i DiVA

Fulltext saknas i DiVA

Övriga länkar

Förlagets fulltext

Person

Challis, PontusSpäth, CorneliaStoltz Sjöström, ElisabethDomellöf, Magnus

Sök vidare i DiVA

Av författaren/redaktören
Challis, PontusSpäth, CorneliaStoltz Sjöström, ElisabethDomellöf, Magnus
Av organisationen
Pediatrik
I samma tidskrift
Archives of Disease in Childhood
Medicin och hälsovetenskap

Sök vidare utanför DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetricpoäng

doi
urn-nbn
Totalt: 291 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf