Umeå University's logo

umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Fibre typing of intrafusal fibres
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB).
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB).
Umeå University, Faculty of Medicine, Department of Odontology, Clinical Oral Physiology.
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB).
Show others and affiliations
2015 (English)In: Journal of Anatomy, ISSN 0021-8782, E-ISSN 1469-7580, Vol. 227, no 2, p. 136-156Article, review/survey (Refereed) Published
Abstract [en]

The first descriptions of muscle spindles with intrafusal fibres containing striated myofibrils and nervous elements were given approximately 150years ago. It took, however, another 100years to establish the presence of two types of intrafusal muscle fibres: nuclear bag and nuclear chain fibres. The present paper highlights primarily the contribution of Robert Banks in fibre typing of intrafusal fibres: the confirmation of the principle of two types of nuclear bag fibres in mammalian spindles and the variation in occurrence of a dense M-band along the fibres. Furthermore, this paper summarizes how studies from the Umea University group (Laboratory of Muscle Biology in the Department of Integrative Medical Biology) on fibre typing and the structure and composition of M-bands have contributed to the current understanding of muscle spindle complexity in adult humans as well as to muscle spindle development and effects of ageing. The variable molecular composition of the intrafusal sarcomeres with respect to myosin heavy chains and M-band proteins gives new perspectives on the role of the intrafusal myofibrils as stretch-activated sensors influencing tension/stiffness and signalling to nuclei.

Place, publisher, year, edition, pages
John Wiley & Sons, 2015. Vol. 227, no 2, p. 136-156
Keywords [en]
cytoskeleton, M-band, M-protein, muscle spindle, myomesin, nuclear bag, nuclear chain, titin
National Category
Other Biological Topics Other Medical Sciences
Identifiers
URN: urn:nbn:se:umu:diva-106768DOI: 10.1111/joa.12338ISI: 000357951900004PubMedID: 26179023Scopus ID: 2-s2.0-84937019487OAI: oai:DiVA.org:umu-106768DiVA, id: diva2:847528
Funder
Swedish Research Council, K2012-63x-20399-06-3Magnus Bergvall FoundationAvailable from: 2015-08-20 Created: 2015-08-07 Last updated: 2023-03-24Bibliographically approved

Open Access in DiVA

fulltext(3522 kB)87 downloads
File information
File name FULLTEXT01.pdfFile size 3522 kBChecksum SHA-512
96ad5ef6de5ef47c4bc8db949af6662a8fb5d7297aebba29b946b319f07e19869eff0f22b50c326a2fdeac12a879f09152a95f604bb975c03d07f148dae06a0a
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMedScopus

Authority records

Thornell, Lars-EricCarlsson, LenaEriksson, Per-OlofLiu, Jing-XiaÖsterlund, CatharinaStål, PerPedrosa-Domellöf, Fatima

Search in DiVA

By author/editor
Thornell, Lars-EricCarlsson, LenaEriksson, Per-OlofLiu, Jing-XiaÖsterlund, CatharinaStål, PerPedrosa-Domellöf, Fatima
By organisation
Department of Integrative Medical Biology (IMB)Clinical Oral PhysiologyOphthalmology
In the same journal
Journal of Anatomy
Other Biological TopicsOther Medical Sciences

Search outside of DiVA

GoogleGoogle Scholar
Total: 87 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 955 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf