The main purpose of this study is to investigate whether self-efficacy in children with disabilities could be strengthened through targeted and adapted physical activities led by specially educated leaders. Children and Youth Physical Self-Perception Profile (CY-PSPP) scale were used. The study includes 45 children of 8–14 years of age with different types of impairments. The children participated in training sessions twice a week and tried out 13 different physical activities during eight months. The median in this study of total self-efficacy was 104 points, which can be compared to median points varying between 100 and 107 in previous studies based on children without disabilities. Furthermore, there was a statistically significant increase of the means in four out of six different domains of self-efficacy before and after the study was carried out. Key findings indicated that this model is successful in strengthening the children’s self-efficacy and that their perceived self-efficacy was equal to that of children without disabilities.