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Surgical Replacement of Implantable Pulse Generator in Deep Brain Stimulation: Adverse Events and Risk Factors in a Multicenter Cohort
Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap, Klinisk neurovetenskap. Neurosurgery, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm. Asia-Pacific Centre for Neuromodulation, Queensland Brain Institute, University of Queensland.
Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap, Klinisk neurovetenskap. Department of Neurosurgery, Sahlgrenska University Hospital, Göteborg.
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2016 (Engelska)Ingår i: Stereotactic and Functional Neurosurgery, ISSN 1011-6125, E-ISSN 1423-0372, Vol. 94, nr 4, s. 235-239Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: Deep brain stimulation (DBS) is a growing treatment modality, and most DBS systems require replacement of the implantable pulse generator (IPG) every few years. The literature regarding the potential impact of adverse events of IPG replacement on the longevity of DBS treatments is rather scarce. Objective: To investigate the incidence of adverse events, including postoperative infections, associated with IPG replacements in a multicenter cohort. Methods: The medical records of 808 patients from one Australian and five Swedish DBS centers with a total of 1,293 IPG replacements were audited. A logistic regression model was used to ascertain the influence of possible predictors on the incidence of adverse events. Results: The overall incidence of major infections was 2.3% per procedure, 3.7% per patient and 1.7% per replaced IPG. For 28 of 30 patients this resulted in partial or complete DBS system removal. There was an increased risk of infection for males (OR 3.6, p = 0.026), and the risk of infection increased with the number of prior IPG replacements (OR 1.6, p < 0.005). Conclusions: The risk of postoperative infection with DBS IPG replacement increases with the number of previous procedures. There is a need to reduce the frequency of IPG replacements. 

Ort, förlag, år, upplaga, sidor
2016. Vol. 94, nr 4, s. 235-239
Nationell ämneskategori
Kirurgi
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URN: urn:nbn:se:umu:diva-128489DOI: 10.1159/000447521ISI: 000387199800005PubMedID: 27554079Scopus ID: 2-s2.0-84983738531OAI: oai:DiVA.org:umu-128489DiVA, id: diva2:1052026
Tillgänglig från: 2016-12-05 Skapad: 2016-12-05 Senast uppdaterad: 2023-03-24Bibliografiskt granskad

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Fytagoridis, AndersSamuelsson, JenniferBlomstedt, Patric

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