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Decreasing prevalence of abdominal aortic aneurysm and changes in cardiovascular risk factors
Umeå universitet, Medicinska fakulteten, Institutionen för kirurgisk och perioperativ vetenskap, Kirurgi.
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Medicin. (Skellefteå Research Unit ; Arcum)ORCID-id: 0000-0002-0350-2132
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Medicin.
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2017 (Engelska)Ingår i: Journal of Vascular Surgery, ISSN 0741-5214, E-ISSN 1097-6809, Vol. 65, nr 3, s. 651-658Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

OBJECTIVE: A significant reduction in the incidence of cardiovascular disease, including abdominal aortic aneurysm (AAA), has been observed in the past decades. In this study, a small but geographically well defined and carefully characterized population, previously screened for AAA and risk factors, was re-examined 11 years later. The aim was to study the reduction of AAA prevalence and associated factors.

METHODS: All men and women aged 65 to 75 years living in the Norsjö municipality in northern Sweden in January 2010 were invited to an ultrasound examination of the abdominal aorta, registration of body parameters and cardiovascular risk factors, and blood sampling. An AAA was defined as an infrarenal aortic diameter ≥30 mm. Results were compared with a corresponding investigation conducted in 1999 in the same region.

RESULTS: A total of 602 subjects were invited, of whom 540 (90%) accepted. In 2010, the AAA prevalence was 5.7% (95% confidence interval [CI], 2.8%-8.5%) among men compared with 16.9% (95% CI, 12.3%-21.6%) in 1999 (P < .001). The corresponding figure for women was 1.1% (95% CI, 0.0%-2.4%) vs 3.5% (95% CI, 1.2%-5.8%; P = .080). A low prevalence of smoking was observed in 2010 as well as in 1999, with only 13% and 10% current smokers, respectively (P = .16). Treatment for hypertension was significantly more common in 2010 (58% vs 44%; P < .001). Statins increased in the population (34% in 2010 vs 3% in 1999; P < .001), and the lipid profile in women had improved significantly between 1999 and 2010.

CONCLUSIONS: A highly significant reduction in AAA prevalence was observed during 11 years in Norsjö. Treatment for hypertension and with statins was more frequent, whereas smoking habits remained low. This indicates that smoking is not the only driver behind AAA occurrence and that lifestyle changes and treatment of cardiovascular risk factors may play an equally important role in the observed recent decline in AAA prevalence.

Ort, förlag, år, upplaga, sidor
2017. Vol. 65, nr 3, s. 651-658
Nationell ämneskategori
Kardiologi och kardiovaskulära sjukdomar
Identifikatorer
URN: urn:nbn:se:umu:diva-128529DOI: 10.1016/j.jvs.2016.08.091ISI: 000397987900034PubMedID: 27793513Scopus ID: 2-s2.0-85006041113OAI: oai:DiVA.org:umu-128529DiVA, id: diva2:1052442
Tillgänglig från: 2016-12-06 Skapad: 2016-12-06 Senast uppdaterad: 2025-09-15Bibliografiskt granskad
Ingår i avhandling
1. Aspects of aneurysm epidemiology
Öppna denna publikation i ny flik eller fönster >>Aspects of aneurysm epidemiology
2025 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Abstract [en]

Background:

The Västerbotten County in Northern Sweden, and particularly Norsjö municipality, has historically had a high burden of cardiovascular disease, and abdominal aortic aneurysm (AAA).

Aims:

To investigate aspects of aneurysm epidemiology in a population with historically high cardiovascular disease and AAA incidence; specifically:(I)to study the AAA prevalence and associated risk factors in a high-risk population;(II)to study popliteal artery diameter and prevalence of popliteal artery aneurysm (PAA) in a high-risk population;(III) to study risk factors associated with the development of AAA and thoracic aortic aneurysm (TAA);(IV)to study dietary factors and risk for development of AAA and TAA.

Methods & Results:

Population-based screening in Norsjö (ages 65–75) showed a significant decline in AAA prevalence among men (16.9% in 1999 → 5.7% in 2010) and a nonsignificant decline in women (3.5% → 1.1%). Compared to 1999, lipid profiles, BMI, and blood pressure control improved, while smoking remained unchanged at low levels. PAA prevalence ≥12 mm was 3.8% in men and 0% in women; most were small and benign with slow growth rates. In a population-based case-control study, using the prospective VIP/MONICA cohort 1985–2010, smoking, hypertension, hyperlipidemia, and coronary artery disease were significantly associated with later AAA development, while only hypertension was associated with TAA development. In the same case-control cohorts, a weak inverse association between AAA and adherence to a Mediterranean diet or high fruit/vegetable intake was observed.

Conclusion:

The sharp decline in AAA prevalence in Norsjö was mainly attributed to improved cardiovascular risk factors, including diet, rather than smoking habits (as suggested in the literature). AAA and TAA show distinct risk factor profiles, indicating partly different etiologies. PAA is rare, and small screening-detected PAAs appear largely benign.

Ort, förlag, år, upplaga, sidor
Umeå: Umeå University, 2025. s. 59
Serie
Umeå University medical dissertations, ISSN 0346-6612 ; 2382
Nyckelord
Abdominal aortic aneurysm, thoracic aortic aneurysm, popliteal artery aneurysm, screening, diet, health interventions, risk factors
Nationell ämneskategori
Kirurgi
Forskningsämne
kirurgi
Identifikatorer
urn:nbn:se:umu:diva-244202 (URN)978-91-8070-796-1 (ISBN)978-91-8070-797-8 (ISBN)
Disputation
2025-10-10, Hörsal B, utbildningsnod T9, Norrlands universitetssjukhus, Umeå, 13:00 (Svenska)
Opponent
Handledare
Tillgänglig från: 2025-09-19 Skapad: 2025-09-15 Senast uppdaterad: 2025-09-17Bibliografiskt granskad

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Persson, Sven-ErikBoman, KurtCarlberg, BoArnerlöv, Conny

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