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Implantable cardioverter defibrillator treatment in long QT syndrome patients: a national study on adherence to international guidelines
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Pediatrik.
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Kardiologi.ORCID-id: 0000-0001-5275-2544
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Kardiologi.ORCID-id: 0000-0002-1811-225X
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Pediatrik.ORCID-id: 0000-0001-9655-7783
2017 (Engelska)Ingår i: Scandinavian Cardiovascular Journal, ISSN 1401-7431, E-ISSN 1651-2006, Vol. 51, nr 2, s. 88-94Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Objectives. Implantable cardioverter defibrillator (ICD) treatment is effective among long QT syndrome (LQTS) patients at a high risk of sudden cardiac death. Previous studies show that the international guidelines are not always followed, and that risk stratification may be based on genotype rather than individual risk profile. We analysed data from the Swedish ICD & Pacemaker Registry and medical records to examine how international guidelines were followed with regards to phenotype and genotype. Methods and results. ICD treatment was used in 150 Swedish LQTS patients from 1989-2013. The annual number of implantations increased over the study period. A total of 109 patients were included in the analysis. Most patients (91%) were symptomatic before the implantation. Seventy percent of patients who received ICD treatment met the 2006 Class I or Class IIa recommendations for LQTS treatment. Thirty-one percent of the LQT3 patients received ICD treatment despite being asymptomatic. Among LQT1 patients, 45% received ICD treatment after syncope despite beta-blockers. Conclusions. Thirty percent of Swedish LQTS patients with ICD received the treatment without a strong indication based on international guidelines. LQT3 patients were over-represented among asymptomatic patients. Many LQT1 patients received ICD despite the known effect of beta-blockers in this group.

Ort, förlag, år, upplaga, sidor
2017. Vol. 51, nr 2, s. 88-94
Nyckelord [en]
Long QT syndrome, implantable cardioverter defibrillator, guidelines, beta-blocker treatment, orted cardiac arrest, syncope
Nationell ämneskategori
Kardiologi
Identifikatorer
URN: urn:nbn:se:umu:diva-133734DOI: 10.1080/14017431.2016.1270463ISI: 000395166500005PubMedID: 27936942Scopus ID: 2-s2.0-85007497525OAI: oai:DiVA.org:umu-133734DiVA, id: diva2:1093784
Tillgänglig från: 2017-05-08 Skapad: 2017-05-08 Senast uppdaterad: 2023-03-24Bibliografiskt granskad

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Sundström, EmiliaJensen, Steen M.Diamant, Ulla-BrittRydberg, Annika

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Sundström, EmiliaJensen, Steen M.Diamant, Ulla-BrittRydberg, Annika
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Scandinavian Cardiovascular Journal
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