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Higher Striatal Iron Concentration is Linked to Frontostriatal Underactivation and Poorer Memory in Normal Aging
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2017 (Engelska)Ingår i: Cerebral Cortex, ISSN 1047-3211, E-ISSN 1460-2199, Vol. 27, nr 6, s. 3427-3436Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

In the brain, intracellular iron is essential for cellular metabolism. However, an overload of free iron is toxic, inducing oxidative stress and cell death. Although an increase of striatal iron has been related to atrophy and impaired cognitive performance, the link between elevated iron and altered brain activity in aging remains unexplored. In a sample of 37 younger and older adults, we examined whether higher striatal iron concentration could underlie age-related differences in frontostriatal activity induced by mental imagery of motor and non-motor scenes, and poorer recall of the scenes. Higher striatal iron concentration was linked to underrecruitment of frontostriatal regions regardless of age and striatal volume, the iron-activity association in right putamen being primarily driven by the older adults. In older age, higher striatal iron was related to poorer memory. Altered astrocytic functions could account for the link between brain iron and brain activity, as astrocytes are involved in iron buffering, neurovascular coupling, and synaptic activity. Our preliminary findings, which need to be replicated in a larger sample, suggest a potential frontostriatal target for intervention to counteract negative effects of iron accumulation on brain function and cognition.

Ort, förlag, år, upplaga, sidor
OXFORD UNIV PRESS INC , 2017. Vol. 27, nr 6, s. 3427-3436
Nyckelord [en]
aging, brain iron, functional MRI, imagery, memory
Nationell ämneskategori
Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi
Identifikatorer
URN: urn:nbn:se:umu:diva-137050DOI: 10.1093/cercor/bhx045ISI: 000402824700025Scopus ID: 2-s2.0-85026890044OAI: oai:DiVA.org:umu-137050DiVA, id: diva2:1117020
Tillgänglig från: 2017-06-28 Skapad: 2017-06-28 Senast uppdaterad: 2023-03-24Bibliografiskt granskad

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Salami, Alireza

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Umeå centrum för funktionell hjärnavbildning (UFBI)Institutionen för integrativ medicinsk biologi (IMB)
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Cerebral Cortex
Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi

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