Umeå University's logo

umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • apa-6th-edition.csl
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Sustained Psoriasis Area and Severity Index, DermatologyLife Quality Index and EuroQol-5D response of biologicaltreatment in psoriasis: 10 years of real-world data in theSwedish National Psoriasis Register
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Dermatology and Venerology.ORCID iD: 0000-0002-3858-8474
2018 (English)In: British Journal of Dermatology, ISSN 0007-0963, E-ISSN 1365-2133, Vol. 178, no 1, p. 245-252Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Few studies have analysed the long-term effects of biological treatment in psoriasis. PsoReg, the Swedish national register for systemic psoriasis treatment, started in 2006 and includes now ten years of real-world data on effectiveness of biological treatment.

OBJECTIVE: To analyse long-term real-world outcome data on biological-naïve patients with moderate to severe psoriasis after switching to biological treatment.

METHODS: Observational study including biological-naïve patients with at least one registration of outcome before switching to biological treatment while included in PsoReg and at least one follow-up visit. PASI, DLQI and EQ-5D values were analysed at 3-5 months, 6-11 months, and at least once 1 year and above, up to 9 years after switch to biological treatment.

RESULTS: 583 patients fulfilled the inclusion criteria. Of these, 399/395/373 patients had observed outcome data beyond one year on PASI/DLQI/EQ-5D, respectively, and 164/168/152 were observed in at least three time periods after switch. Significant (p<0.01) improvement in PASI, DLQI and EQ-5D was observed 3-5 months after switch and sustained under the whole observation period. Mean PASI/DLQI/EQ-5D changed from 13.5 (SD 9.1)/9.0 (SD 8.1)/0.737 (SD 0.222), respectively, before switch, to 4.0 (SD 3.5)/3.7 (SD 4.7)/0.792 (SD 0.208), respectively, 1-5 years after switch.

CONCLUSION: Biological treatment, as used in clinical practice, show a stable long term effectiveness in all measured dimensions: PASI, DLQI and EQ-5D.

Place, publisher, year, edition, pages
Hoboken: John Wiley & Sons, 2018. Vol. 178, no 1, p. 245-252
National Category
Dermatology and Venereal Diseases
Identifiers
URN: urn:nbn:se:umu:diva-137285DOI: 10.1111/bjd.15757ISI: 000435470700077PubMedID: 28644904Scopus ID: 2-s2.0-85040172867OAI: oai:DiVA.org:umu-137285DiVA, id: diva2:1117438
Available from: 2017-06-29 Created: 2017-06-29 Last updated: 2023-09-05Bibliographically approved

Open Access in DiVA

fulltext(1467 kB)824 downloads
File information
File name FULLTEXT01.pdfFile size 1467 kBChecksum SHA-512
3f54e7d7b5846f961148b91b412618be9eec34b6c8c9c6dacdc07d1fd165ae246dfec7045ba9af7a88f6d1ce9533fb4274d6a811375748e74fb3ddd5d6e5c992
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMedScopus

Authority records

Schmitt-Egenolf, Marcus

Search in DiVA

By author/editor
Schmitt-Egenolf, Marcus
By organisation
Dermatology and Venerology
In the same journal
British Journal of Dermatology
Dermatology and Venereal Diseases

Search outside of DiVA

GoogleGoogle Scholar
Total: 824 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 760 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • apa-6th-edition.csl
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf