Umeå universitets logga

umu.sePublikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Weight loss by two different diets increases the postprandial response of GLP-1 but only the Paleolithic diet increases the postprandial response of GIP
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Medicin.
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Medicin.
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Medicin.
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin.
Visa övriga samt affilieringar
2017 (Engelska)Ingår i: Diabetologia, ISSN 0012-186X, E-ISSN 1432-0428, Vol. 60, s. S233-S233Artikel i tidskrift, Meeting abstract (Övrigt vetenskapligt) Published
Abstract [en]

Background and aims: Weight loss by diet intervention has shown conflicting results on postprandial levels of glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). We therefore investigated a Paleolithic diet (PD) and a prudent control diet according to the Nordic nutrition recommendations (CD) and aimed to compare the effect of the two diets on postprandial levels of GLP-1 and GIP.

Materials and methods: Seventy healthy, obese, postmenopausal women were randomized to either the PD or the CD. In the PD group participants were advised to eat vegetables, fruit, lean meat, fish, nuts and eggs. Cereals, dairy products, added sugar and salt were excluded. With the CD participants were advised to increase their intake of whole grain, fruit, vegetables and fish. Dairy products and meat were supposed to be low fat. Both diets were without calorie restriction. Plasma levels of GLP-1 and GIP were measured after ingestion of 75 g glucose at baseline and after 6 and 24 months of diet intervention. The incremental area under the curve (iAUC) of GLP-1 and GIP was calculated during 120 min after glucose intake.

Results: The PD group showed a more pronounced weight reduction after 6 months (9.2 ± 4.2 kg (mean±SD)) and 24 months (8.1 ± 5.6 kg) compared to the CD group (4.7 ± 4.2 kg at 6 months and 4.9 ± 4.8 kg at 24 months; P<0.001 and P<0.05 for the difference between groups at 6 months and 24 months). For the PD group the iAUC of GLP-1 increased by 34 % after 6 months and by 45 % after 24 months compared to baseline. For the CD group the iAUC of GLP-1 increased by 11 % after 6 months and by 59 % after 24 months. For the PD group the iAUC of GIP increased by 23 % after 6 months compared to baseline but decreased by 3 % in the CD group (P<0.05 for the difference between groups).

Conclusion: Postprandial levels of GLP-1 increased through dietinduced weight loss by the Paleolithic diet and the control diet. The postprandial GIP response increased through weight loss by the Paleolithic diet but not by the control diet.

Ort, förlag, år, upplaga, sidor
Springer, 2017. Vol. 60, s. S233-S233
Nationell ämneskategori
Endokrinologi och diabetes
Identifikatorer
URN: urn:nbn:se:umu:diva-140913DOI: 10.1007/s00125-017-4350-zISI: 000408315001288OAI: oai:DiVA.org:umu-140913DiVA, id: diva2:1158473
Konferens
53rd Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Lisbon, Portugal, September 11-15, 2017
Anmärkning

Supplement:1, Meeting Abstract: 511

Tillgänglig från: 2017-11-20 Skapad: 2017-11-20 Senast uppdaterad: 2020-08-04Bibliografiskt granskad

Open Access i DiVA

Fulltext saknas i DiVA

Övriga länkar

Förlagets fulltext

Person

Otten, JuliaRyberg, MatsMellberg, Caroline

Sök vidare i DiVA

Av författaren/redaktören
Otten, JuliaRyberg, MatsMellberg, Caroline
Av organisationen
MedicinInstitutionen för folkhälsa och klinisk medicin
I samma tidskrift
Diabetologia
Endokrinologi och diabetes

Sök vidare utanför DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetricpoäng

doi
urn-nbn
Totalt: 550 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf