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Relapsing Fevers: Neglected Tick-Borne Diseases
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS).
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2018 (English)In: Frontiers in Cellular and Infection Microbiology, E-ISSN 2235-2988, Vol. 8, article id 98Article, review/survey (Refereed) Published
Abstract [en]

Relapsing fever still remains a neglected disease and little is known on its reservoir, tick vector and physiopathology in the vertebrate host. The disease occurs in temperate as well as tropical countries. Relapsing fever borreliae are spirochaetes, members of the Borreliaceae family which also contain Lyme disease spirochaetes. They are mainly transmitted by Ornithodoros soft ticks, but some species are vectored by ixodid ticks. Traditionally a Borrelia species is associated with a specific vector in a particular geographical area. However, new species are regularly described, and taxonomical uncertainties deserve further investigations to better understand Borrelia vector/host adaptation. The medical importance of Borrelia miyamotoi, transmitted by Ixodes spp., has recently spawned new interest in this bacterial group. In this review, recent data on tick-host-pathogen interactions for tick-borne relapsing fevers is presented, with special focus on B. miyamotoi.

Place, publisher, year, edition, pages
Frontiers Media S.A., 2018. Vol. 8, article id 98
Keywords [en]
relapsing fever, Borrelia, Ornithodoros, hard ticks, Borrelia miyamotoi, neurotropism, antigenic riations
National Category
Infectious Medicine
Identifiers
URN: urn:nbn:se:umu:diva-148629DOI: 10.3389/fcimb.2018.00098ISI: 000429178000002PubMedID: 29670860Scopus ID: 2-s2.0-85045051237OAI: oai:DiVA.org:umu-148629DiVA, id: diva2:1222512
Available from: 2018-06-21 Created: 2018-06-21 Last updated: 2018-06-21Bibliographically approved

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Bergström, Sven

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