Umeå University's logo

umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Exercise habits and C-reactive protein may predict development of spinal immobility in patients with ankylosing spondylitis
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Rheumatology.ORCID iD: 0000-0001-7226-0969
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Rheumatology. Clinical Epidemiology Section, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Rheumatology.
2018 (English)In: Clinical Rheumatology, ISSN 0770-3198, E-ISSN 1434-9949, Vol. 37, no 10, p. 2881-2885Article in journal (Refereed) Published
Abstract [en]

To assess predictors for spinal immobility in a long-term clinical study of patients with AS, data from annual clinical measurements of spinal mobility in 54 patients (41 men, mean of age at end of follow-up 54.7 years) with ankylosing spondylitis were co-analysed with data regarding lifestyle factors as well as laboratory measurements from a previous cross-sectional study. Spinal immobility was graded on the basis of recently published age-, sex- and length-specific reference intervals. Exercise habits and high-sensitivity C-reactive protein (hsCRP) were independently associated with the development of subnormal spinal immobility (p = 0.019 and p = 0.021). In multiple regression models, approximately 25% of the spinal immobility could be attributed to disease duration (p ae 0.011), levels of hsCRP (p ae0.004) and exercise in leisure time (p ae 0.019). The mean concentration of hsCRP was 4.2 mg/L (range 0.2-8.4 mg/L) in the study cohort. Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), erythrocyte sedimentation rate (ESR) and physical activity at work were not associated with spinal immobility. The results indicate that exercise habits may have an impact in preventing the development of spinal immobility in AS independently of disease duration and inflammation. This corresponds well with the accumulated knowledge from long-term clinical experience among rheumatologists, health professionals and patients. Consequently, exercise should remain an important part of the non-pharmacological treatment and self-care for patients with AS. Furthermore, modest inflammatory activity, measured as a slightly elevated hsCRP concentration, appears to affect subsequent spinal immobility in AS.

Place, publisher, year, edition, pages
Springer London, 2018. Vol. 37, no 10, p. 2881-2885
Keywords [en]
Ankylosing spondylitis, Biomarkers, Exercise, Physical activity
National Category
Rheumatology and Autoimmunity
Identifiers
URN: urn:nbn:se:umu:diva-152384DOI: 10.1007/s10067-018-4195-yISI: 000444749500036PubMedID: 30022369Scopus ID: 2-s2.0-85050270182OAI: oai:DiVA.org:umu-152384DiVA, id: diva2:1253736
Funder
Norrbotten County CouncilVästerbotten County CouncilSwedish Rheumatism AssociationAvailable from: 2018-10-05 Created: 2018-10-05 Last updated: 2023-03-24Bibliographically approved

Open Access in DiVA

fulltext(814 kB)191 downloads
File information
File name FULLTEXT01.pdfFile size 814 kBChecksum SHA-512
88e45def2eebd5f69a3a74f54bded204a1533428cb4c0b6f2aac4402eaacae17ee8cb91e63563e0bbe5501e3b8666769acedadc7a0b7068e6179f8ebf244fd11
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMedScopus

Authority records

Sundström, BjörnLjung, Lotta

Search in DiVA

By author/editor
Sundström, BjörnLjung, LottaWallberg-Jonsson, Solveig
By organisation
Rheumatology
In the same journal
Clinical Rheumatology
Rheumatology and Autoimmunity

Search outside of DiVA

GoogleGoogle Scholar
Total: 191 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 211 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf