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The impact of comorbidities on mortality in COPD, report from the OLIN COPD study.
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Medicin.
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin. (OLIN Unit)ORCID-id: 0000-0002-1630-3167
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin. (OLIN Unit)ORCID-id: 0000-0002-0553-8067
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin. (OLIN Unit)
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2018 (Engelska)Ingår i: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 52Artikel i tidskrift, Meeting abstract (Övrigt vetenskapligt) Published
Abstract [en]

Comorbidities contribute to the increased mortality observed among subjects with COPD, but the prognostic impact and possible sex differences have rarely been evaluated in population-based studies.

Aim: To evaluate the impact of common comorbidities; cardiovascular disease (CVD), diabetes mellitus (DM) and anxiety/depression (A/D), on mortality in a population-based study of subjects with (COPD) and without airway obstruction.

Methods: All subjects with airway obstruction (FEV1/(F)VC<0.70, n=993), were, together with age- and sex matched referents, identified after examinations of population-based cohorts in 2002-04. Spirometric groups: Normal Lung Function (NLF), COPD; post- bronchodilator fixed ratio (GOLD) and lower limit of normal (LLN). Mortality data were collected until December 2015.

Results: The cumulative mortality was significantly higher in GOLD-COPD than NLF, and higher in men than women in both groups. CVD, DM and A/D independently increased the risk for death (Hazard Ratio; 95% CI, 1.50-1.59; 1.07-2.11) in GOLD-COPD when adjusted for age, sex, smoking habits, BMI and FEV1% predicted, while in NLF A/D (1.54; 1.03-2.30) but not CVD (1.20; 0.87-1.65) or DM (1.46; 0.95-2.26). Among women with GOLD-COPD, CVD and A/D but not DM increased the risk for death, while among men DM and A/D, but not CVD. When the LLN-criterion was applied, the significantly increased risk for death associated with comorbidities remained among men, but not among women.

Conclusion: CVD, DM and A/D increased the risk for death in GOLD-COPD, but there seems to be sex-dependent differences in prognosis associated with comorbidities, also in relation to different spirometric criteria for COPD.

Ort, förlag, år, upplaga, sidor
European Respiratory Society , 2018. Vol. 52
Identifikatorer
URN: urn:nbn:se:umu:diva-155994DOI: 10.1183/13993003.congress-2018.PA2269ISI: 000455567102374OAI: oai:DiVA.org:umu-155994DiVA, id: diva2:1286499
Konferens
28th International Congress of the European-Respiratory-Society (ERS), SEP 15-19, 2018, Paris, FRANCE
Anmärkning

Supplement: 62

Meeting Abstract: PA2269

Tillgänglig från: 2019-02-07 Skapad: 2019-02-07 Senast uppdaterad: 2024-07-02Bibliografiskt granskad

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Sawalha, SamiHedman, LinneaBackman, HelenaRönmark, EvaStenfors, NikolaiLindberg, Anne

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Sawalha, SamiHedman, LinneaBackman, HelenaRönmark, EvaStenfors, NikolaiLindberg, Anne
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MedicinInstitutionen för folkhälsa och klinisk medicin
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European Respiratory Journal

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