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NADH oxidation drives respiratory Na+ transport in mitochondria from Yarrowia lipolytica
Biochemisches Institut, Universität Zürich, Zurich, Switzerland, Unité de Pathogénie Microbienne Moléculaire, Institut Pasteur, Paris Cedex 15, France.ORCID-id: 0000-0002-9915-002x
2008 (Engelska)Ingår i: Archives of Microbiology, ISSN 0302-8933, E-ISSN 1432-072X, Vol. 190, nr 4, s. 471-480Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

It is generally assumed that respiratory complexes exclusively use protons to energize the inner mitochondrial membrane. Here we show that oxidation of NADH by submitochondrial particles (SMPs) from the yeast Yarrowia lipolytica is coupled to protonophore-resistant Na+ uptake, indicating that a redox-driven, primary Na+ pump is operative in the inner mitochondrial membrane. By purification and reconstitution into proteoliposomes, a respiratory NADH dehydrogenase was identified which coupled NADH-dependent reduction of ubiquinone (1.4 micromol min(-1) mg(-1)) to Na+ translocation (2.0 micromol min(-1) mg(-1)). NADH-driven Na+ transport was sensitive towards rotenone, a specific inhibitor of complex I. We conclude that mitochondria from Y. lipolytica contain a NADH-driven Na+ pump and propose that it represents the complex I of the respiratory chain. Our study indicates that energy conversion by mitochondria does not exclusively rely on the proton motive force but may benefit from the electrochemical Na+ gradient established by complex I.

Ort, förlag, år, upplaga, sidor
2008. Vol. 190, nr 4, s. 471-480
Nationell ämneskategori
Mikrobiologi Biokemi och molekylärbiologi
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URN: urn:nbn:se:umu:diva-156950DOI: 10.1007/s00203-008-0395-1PubMedID: 18551278OAI: oai:DiVA.org:umu-156950DiVA, id: diva2:1293127
Tillgänglig från: 2019-03-03 Skapad: 2019-03-03 Senast uppdaterad: 2019-03-11Bibliografiskt granskad

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Puhar, Andrea

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