Umeå universitets logga

umu.sePublikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
The rough journey to access health care: the case of leishmaniasis in the Bolivian rainforest
Umeå universitet, Medicinska fakulteten, Institutionen för epidemiologi och global hälsa.
2019 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Abstract [en]

Background: Leishmaniasis is a parasitic infectious disease transmitted by vectors that cause three main clinical syndromes: cutaneous (CL), mucosal (ML), and visceral (VL). Since VL is not relevant to this thesis, only CL and ML will be further discussed. Leishmaniasis is present in 98 countries, with more than 350 million people at risk of infection. Leishmaniasis disproportionately affects poor countries and, in particular, remote areas where health services are weaker. Bolivia, a lower-middle-income country, is the fifth country with more cases in Latin America, and case detection and management is the main control strategy of the National Leishmaniasis Control Programme (NLCP). The NLCP provides free treatment to patients, which consists of systemic pentavalent antimonials (SPA) for 20 days. This treatment is highly toxic for patients and costly for the government, resulting in long periods of shortage of the drug. A good alternative to SPA is the use of intralesional pentavalent antimonials (ILPA), which are safer and have similar efficacy to SPA in treating CL. Case detection and management depend on a well-structured health-care system, and the primary level of care is responsible for this task in Bolivian endemic areas. It is well known that health-care access for leishmaniasis patients is limited but the extent and the determinant factors of this problem are unknown. The aim of this thesis is to assess health-care access among patients with leishmaniasis in a Bolivian rainforest rural area, addressing four specific questions: Who is most vulnerable to CL?; What is the extent of their lack of access to health care?; How do the dimensions of access and the quality of care influence health-care utilization in a context of vulnerability?; and how can a change in NLCP policy related to the treatment of CL improve the level of access to health care?

Methods: This thesis is based on four studies that use quantitative and qualitative methods. Data collection was conducted through surveys, in-depth interviews and revision of official documents. Sub-study 1 was based on a cross-sectional study conducted in two communities of Cochabamba and assessed risk factors for CL using multivariate analysis. Sub-study 2 used the method of capture−recapture to assess the level of under-reporting of the national register for the period of 2013−2014,  using Chapman’s formula. Sub-study 3 was conducted through in-depth interviews applied to 14 participants, using thematic analysis. Sub-study 4 was an economic evaluation that used data from surveys with physicians, official documents and key informants and compared the costs of systemic pentavalent antimonials (SPA) and intralesional pentavalent antimonials (ILPA) from the perspective of the Ministry of Health (MoH) and society. Additionally, a budget impact analysis of the implementation of ILPA in hypothetical scenarios of increasing level of demand was carried out.

Main findings: Sub-study 1 showed that gender/sex was the only statistically significant factor associated with CL, with men being the most affected group. Other classical factors, such as animal ownership, house materials and protective measures were, however, not related to CL. Sub-study 2 revealed a high level of under-reporting (73%) of CL in the study area, and this under-reporting was higher among men compared to women. Sub-study 3 showed that the lack of availability, accessibility, affordability and quality of care were the main factors that limited the access to care of CL and ML patients. In sub-study 4, the economic analysis pointed out that the use of ILPA was cost-saving for the MoH and society, and the budget analysis confirmed that the implementation of ILPA as first-line treatment was not only cost-saving for the MoH, but it would also increase the number of patients accessing the treatment.

Conclusions: The predominance of a sylvatic pattern of transmission, with men as the most affected group, demands new approaches to prevention related to occupational activities. The NLCP policy related to case management has been essential to reducing economic barriers for patients with leishmaniasis; however, there are still a considerable amount of cases who do not have access to the treatment. Lacko f health services, equipment and drugs, as well as difficulties in reaching health services, the high costs of seeking health care and the low quality of care are important factors that must be addressed to fulfil the right to health care for these patients. Finally, new therapeutic alternatives, such as ILPA, must be considered to reduce problems of affordability, adherence, as well as side effects to the treatment. This information can be used to develop targeted interventions aimed at increasing the access to health care of people with leishmaniasis in the rainforest of Bolivia.

Ort, förlag, år, upplaga, sidor
Umeå: Umeå University , 2019. , s. 77
Serie
Umeå University medical dissertations, ISSN 0346-6612 ; 2009
Nyckelord [en]
Cutaneous leishmaniasis, Health-care access, risk factors, population surveillance, capture-recapture, health care seeking behavior, intralesional pentavalent antimonials, economic analysis, cost analysis, budget impact analysis, Bolivia, rainforest
Nationell ämneskategori
Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi
Forskningsämne
folkhälsa
Identifikatorer
URN: urn:nbn:se:umu:diva-157113ISBN: 978-91-7855-013-5 (tryckt)OAI: oai:DiVA.org:umu-157113DiVA, id: diva2:1295368
Disputation
2019-04-05, Hörsal D, Unod T9, Norrlands universitetssjukhus, Umeå, 09:00 (Engelska)
Opponent
Handledare
Tillgänglig från: 2019-03-15 Skapad: 2019-03-11 Senast uppdaterad: 2019-03-14Bibliografiskt granskad
Delarbeten
1. Risk factors for cutaneous leishmaniasis in the rainforest of Bolivia: a cross-sectional study
Öppna denna publikation i ny flik eller fönster >>Risk factors for cutaneous leishmaniasis in the rainforest of Bolivia: a cross-sectional study
Visa övriga...
2018 (Engelska)Ingår i: Tropical Medicine and Health, ISSN 1348-8945, E-ISSN 1349-4147, Vol. 46, artikel-id 9Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: Cutaneous leishmaniasis (CL) is an endemic disease in Bolivia, particularly in the rainforest of Cochabamba, in the municipality of Villa Tunari. The precarious, dispersed, and poorly accessible settlements in these farming communities make it difficult to study them, and there are no epidemiological studies in the area. The aim of the present study was to identify the risk factors associated with cutaneous leishmaniasis.

Methods: A cross-sectional study was conducted in August 2015 and August 2016 in two communities of Villa Tunari, Cochabamba. The cases were diagnosed through clinical examinations, identification of the parasite by microscopic examination, and the Montenegro skin test. Risk factors were identified through logistic regression.

Results: A total of 274 participants (40.9% female and 59.1% male) were surveyed, of which 43% were CL positive. Sex was the only factor associated with CL with three times more risk for men than for women; this finding suggests a sylvatic mechanism of transmission in the area.

Conclusions: It is advisable to focus on education and prevention policies at an early age for activities related to either leisure or work. Further research is needed to assess the influence of gender-associated behavior for the risk of cutaneous leishmaniasis.

Nationell ämneskategori
Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi
Identifikatorer
urn:nbn:se:umu:diva-147457 (URN)10.1186/s41182-018-0089-6 (DOI)000430564000001 ()29692654 (PubMedID)2-s2.0-85045401979 (Scopus ID)
Tillgänglig från: 2018-05-29 Skapad: 2018-05-29 Senast uppdaterad: 2023-03-23Bibliografiskt granskad
2. Assessment of a Leishmaniasis Reporting System in Tropical Bolivia Using the Capture-Recapture Method
Öppna denna publikation i ny flik eller fönster >>Assessment of a Leishmaniasis Reporting System in Tropical Bolivia Using the Capture-Recapture Method
Visa övriga...
2018 (Engelska)Ingår i: American Journal of Tropical Medicine and Hygiene, ISSN 0002-9637, E-ISSN 1476-1645, Vol. 98, nr 1, s. 134-138Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

This study evaluates the level of underreporting of the National Program of Leishmaniasis Control (NPLC) in two communities of Cochabamba, Bolivia during the period 2013-2014. Montenegro skin test-confirmed cases of cutaneous leishmaniasis (CL) were identified through active surveillance during medical campaigns. These cases were compared with those registered in the NPLC by passive surveillance. After matching and cleaning data from the two sources, the total number of cases and the level of underreporting of the National Program were calculated using the capture-recapture analysis. This estimated that 86 cases of CL (95% confidence interval [CI]: 62.1-110.8) occurred in the study period in both communities. The level of underreporting of the NPLC in these communities was very high: 73.4% (95% CI: 62.1-110.8). These results can be explained by the inaccessibility of health services and centralization of the NPLC activities. This information is important to establish priorities among policy-makers and funding organizations as well as implementing adequate intervention plans.

Ort, förlag, år, upplaga, sidor
The American Society of Tropical Medicine and Hygiene, 2018
Nationell ämneskategori
Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi
Identifikatorer
urn:nbn:se:umu:diva-142487 (URN)10.4269/ajtmh.17-0308 (DOI)000430950900025 ()29141751 (PubMedID)2-s2.0-85040512633 (Scopus ID)
Tillgänglig från: 2017-11-30 Skapad: 2017-11-30 Senast uppdaterad: 2019-03-13Bibliografiskt granskad
3. Leishmaniasis patients' pilgrimage to access health care in rural Bolivia: a qualitative study using human rights to health approach
Öppna denna publikation i ny flik eller fönster >>Leishmaniasis patients' pilgrimage to access health care in rural Bolivia: a qualitative study using human rights to health approach
2019 (Engelska)Ingår i: BMC International Health and Human Rights, E-ISSN 1472-698X, Vol. 19, nr 1, artikel-id 12Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: Leishmaniasis is a neglected tropical disease endemic in Bolivia that disproportionately affects people with little social and political capital. Although the treatment is provided free of charge by the Bolivian government, there is an under-utilization of treatments in relation to the estimated affected population. This study explores the experiences of patients with leishmaniasis and the challenges faced when searching for diagnosis and treatment in Bolivia using a human rights approach.

Methods: We conducted open-ended interviews with 14 participants diagnosed with leishmaniasis. The qualitative data were analysed using thematic analysis and were interpreted under a human rights approach to health care.

Results: Four themes emerged during data analysis: (1) the decision for seeking a cure takes time; (2) the severity of symptoms and disruption of functioning drives the search for Western medicine; (3) the therapeutic journey between Western and traditional medicine; and (4) accessibility barriers to receive adequate medical treatment. This study showed that access to health care limitations were the most important factors that prevented patients from receiving timely diagnosis and treatment. Cultural factors played a secondary role in their decision to seek medical care.

Conclusions: Accessibility barriers resulted in a large pilgrimage between public health care and traditional medicinal treatments for patients with leishmaniasis. This pilgrimage and the related costs are important factors that determine the decision to seek health care. This study contributes to the understanding of the under-utilisation problems of medical services in leishmaniasis and other similar diseases in remote and poor populations.

Ort, förlag, år, upplaga, sidor
BioMed Central, 2019
Nyckelord
Cutaneous leishmaniasis, human rights, health care, seeking behavior, Bolivia
Nationell ämneskategori
Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi
Forskningsämne
folkhälsa
Identifikatorer
urn:nbn:se:umu:diva-156786 (URN)10.1186/s12914-019-0196-4 (DOI)000460400800001 ()30837001 (PubMedID)2-s2.0-85062487581 (Scopus ID)
Forskningsfinansiär
Sida - Styrelsen för internationellt utvecklingssamarbete, 75000554
Tillgänglig från: 2019-02-28 Skapad: 2019-02-28 Senast uppdaterad: 2024-01-17Bibliografiskt granskad
4. "Cheaper and better": an economic analysis of changing first line treatment for cutaneous leishmaniasis in Bolivia
Öppna denna publikation i ny flik eller fönster >>"Cheaper and better": an economic analysis of changing first line treatment for cutaneous leishmaniasis in Bolivia
(Engelska)Manuskript (preprint) (Övrigt vetenskapligt)
Abstract [en]

Introduction: Cutaneous leishmaniasis (CL) is endemic in Bolivia, mostly affecting poor people in rainforest areas. The current first-line treatment consists of systemic pentavalent antimonials (SPA) for 20 days and is paid for by the Ministry of Health (MoH). Long periods of drug shortages, a lack of conditions to deliver treatment safely, treatment interruption are challenges to implementation. Intralesional pentavalent antimonials (ILPA) are an alternative to SPA. This study aims to compare the cost of ILPA and SPA, and to estimate the health and economic impacts of changing the first-line treatment for CL in an endemic area of Bolivia.

Methods: The cost per patient treated was estimated for SPA and ILPA from the perspectives of the MoH and society. The quantity and unit costs of medications, staff time, transportation and loss of production were obtained through a health facility survey (N=12), official documents and key informants. A one-way sensitivity analysis was conducted on key parameters to evaluate the robustness of the results. The annual number of patients treated and the budget impact of switching to ILPA as the first-line treatment were estimated under different scenarios of increasing treatment utilization using previous estimates of the extent of underreporting. Costs were reported in 2016 international dollars (1 INT$ = 3.10 BOB).

Results: Treating CL using ILPA was associated with a cost saving of $248 per patient treated from the MoH perspective, and $688 per patient treated from the societal perspective. ILPA was cost-saving even under a hypothetical increase of 80% in the number of cases treated. Switching first-line treatment would allow two-and-a-half times the current number of patients to be treated, while maintaining the current budget.

Conclusions: The results of this study support a shift to ILPA as the first-line treatment for CL in Bolivia and possibly in other South American countries.

Nyckelord
Cutaneous leishmaniasis, economic analysis, intralesional pentavalent antimonials, Bolivia, cost analysis
Nationell ämneskategori
Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi
Forskningsämne
folkhälsa
Identifikatorer
urn:nbn:se:umu:diva-156787 (URN)
Forskningsfinansiär
Sida - Styrelsen för internationellt utvecklingssamarbete, 75000554
Tillgänglig från: 2019-02-26 Skapad: 2019-02-26 Senast uppdaterad: 2019-03-19

Open Access i DiVA

fulltext(4142 kB)350 nedladdningar
Filinformation
Filnamn FULLTEXT03.pdfFilstorlek 4142 kBChecksumma SHA-512
a5cd867a867d8e8c0e11dad781b37b3515891775d0e2ffa80305dd0969d69d4b2d0e3e8ef4406c373d95cb7da4127888e9b9ce335e6eed41991f393bda5061e8
Typ fulltextMimetyp application/pdf
spikblad(103 kB)208 nedladdningar
Filinformation
Filnamn FULLTEXT02.pdfFilstorlek 103 kBChecksumma SHA-512
5f46529f353064e73325a97252e5b1ba047ca7f8dec651fbdb3b0348272fca8e48b697b614a42361c5614c51a38390b416468e1fb4464e9d835c915fc51355a8
Typ spikbladMimetyp application/pdf
omslag(4651 kB)58 nedladdningar
Filinformation
Filnamn COVER01.pdfFilstorlek 4651 kBChecksumma SHA-512
9ac694548624a17db32540eadc6dec6324f8985fc125f0d7dc1079a1516b47096f8af6fb0038425b3c988842b9c4c741ef44d293fe06e5507bea4932d7ddfc13
Typ coverMimetyp application/pdf

Sök vidare i DiVA

Av författaren/redaktören
Eid Rodríguez, Daniel V.
Av organisationen
Institutionen för epidemiologi och global hälsa
Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi

Sök vidare utanför DiVA

GoogleGoogle Scholar
Totalt: 558 nedladdningar
Antalet nedladdningar är summan av nedladdningar för alla fulltexter. Det kan inkludera t.ex tidigare versioner som nu inte längre är tillgängliga.

isbn
urn-nbn

Altmetricpoäng

isbn
urn-nbn
Totalt: 1025 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf