Umeå universitets logga

umu.sePublikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Neurotrophic factor BDNF is upregulated in soft palate muscles of snorers and sleep apnea patients
Umeå universitet, Medicinska fakulteten, Institutionen för integrativ medicinsk biologi (IMB).
Umeå universitet, Medicinska fakulteten, Institutionen för integrativ medicinsk biologi (IMB).
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Öron- näs- och halssjukdomar.
Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
Visa övriga samt affilieringar
2019 (Engelska)Ingår i: Laryngoscope Investigative Otolaryngology (LIO), E-ISSN 2378-8038, Vol. 4, nr 1, s. 174-180Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Objectives: Neuromuscular injuries are suggested to contribute to upper airway collapse and swallowing dysfunction in patients with sleep apnea. Neurotrophins, a family of proteins involved in survival, development, and function of neurons, are reported to be upregulated in limb muscle fibers in response to overload and nerve damage. We aimed to investigate the expression of two important neurotrophins, brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF), in muscle fibers of uvula from snorers and sleep apnea patients and to compare these findings with pharyngeal function.

Methods: Uvula muscle biopsies from 22 patients and 10 controls were analyzed for BDNF, NGF, and cytoskeletal protein desmin using immunohistochemistry. Pharyngeal swallowing function was assessed using videoradiography.

Results: BDNF, but not NGF, was significantly upregulated in a subpopulation of muscle fibers in snoring and sleep apnea patients. Two major immunoreaction patterns for BDNF were observed; a fine grainy point like BDNF staining was displayed in muscle fibers of both patients and controls (41 +/- 23 vs. 25 +/- 17%, respectively, P = .06), while an abnormal upregulated intense-dotted or disorganized reaction was mainly observed in patients (8 +/- 8 vs. 2 +/- 2%, P = .02). The latter fibers, which often displayed an abnormal immunoreaction for desmin, were more frequent in patients with than without swallowing dysfunction (10 +/- 8 vs. 3 +/- 3%, P = .05).

Conclusion: BDNF is upregulated in the upper airway muscles of snorers and sleep apnea patients, and especially in patients with swallowing dysfunction. Upregulation of BDNF is suggested to be a response to denervation, reinnervation, and repair of injured muscle fibers. Our findings propose that damaged upper airway muscles might heal following treatment for snoring and sleep apnea.

Ort, förlag, år, upplaga, sidor
Wiley Periodicals, Inc. , 2019. Vol. 4, nr 1, s. 174-180
Nyckelord [en]
Neurotrophins, brain-derived neurotrophic factor (BDNF), nerve-derived neurotrophic factor GF), snorers, obstructive sleep apnea, OSA, swallowing dysfunction, desmin, neuromuscular injury, nerve, muscle fiber
Nationell ämneskategori
Lungmedicin och allergi
Identifikatorer
URN: urn:nbn:se:umu:diva-157217DOI: 10.1002/lio2.225ISI: 000459339700027PubMedID: 30828636Scopus ID: 2-s2.0-85061541196OAI: oai:DiVA.org:umu-157217DiVA, id: diva2:1298719
Tillgänglig från: 2019-03-25 Skapad: 2019-03-25 Senast uppdaterad: 2023-08-25Bibliografiskt granskad

Open Access i DiVA

fulltext(854 kB)295 nedladdningar
Filinformation
Filnamn FULLTEXT01.pdfFilstorlek 854 kBChecksumma SHA-512
68ba2da5a9480ee1482b15c24828be77acc00e20b5f9defa2b06e18ee4cb096d5d926acd1fad9a6dd7e8e7a47806a981767b73dc4e9aff0120229358e2fd73ed
Typ fulltextMimetyp application/pdf

Övriga länkar

Förlagets fulltextPubMedScopus

Person

Shah, FarhanForsgren, StureHolmlund, ThorbjörnBerggren, DianaFranklin, Karl A.Stål, Per

Sök vidare i DiVA

Av författaren/redaktören
Shah, FarhanForsgren, StureHolmlund, ThorbjörnBerggren, DianaFranklin, Karl A.Stål, Per
Av organisationen
Institutionen för integrativ medicinsk biologi (IMB)Öron- näs- och halssjukdomarInstitutionen för odontologiKirurgi
I samma tidskrift
Laryngoscope Investigative Otolaryngology (LIO)
Lungmedicin och allergi

Sök vidare utanför DiVA

GoogleGoogle Scholar
Totalt: 296 nedladdningar
Antalet nedladdningar är summan av nedladdningar för alla fulltexter. Det kan inkludera t.ex tidigare versioner som nu inte längre är tillgängliga.

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 632 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf