Umeå universitets logga

umu.sePublikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Chronic inflammatory diseases, anti-inflammatory medications and risk of prostate cancer: a population-based case-control study
Visa övriga samt affilieringar
2019 (Engelska)Ingår i: BMC Cancer, ISSN 1471-2407, E-ISSN 1471-2407, Vol. 19, artikel-id 612Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: Whether chronic inflammation increases prostate cancer risk remains unclear. This study investigated whether chronic inflammatory diseases (CID) or anti-inflammatory medication use (AIM) were associated with prostate cancer risk.

Methods: Fifty-five thousand nine hundred thirty-seven cases (all prostate cancer, 2007–2012) and 279,618 age-matched controls were selected from the Prostate Cancer Database Sweden. CIDs and AIMs was determined from national patient and drug registers. Associations were investigated using conditional logistic regression, including for disease/drug subtypes and exposure length/dose.

Results: Men with a history of any CID had slightly increased risk of any prostate cancer diagnosis (OR: 1.08; 95%CI: 1.04–1.12) but not ‘unfavourable’ (high-risk or advanced) prostate cancer. Generally, risk of prostate cancer was highest for shorter exposure times. However, a positive association was observed for asthma > 5 years before prostate cancer diagnosis (OR: 1.21; 95%CI: 1.05–1.40). Risk of prostate cancer was increased with prior use of any AIMs (OR: 1.26; 95%CI: 1.24–1.29). A positive trend with increasing cumulative dose was only observed for inhaled glucocorticoids (p < 0.011).

Conclusion: Detection bias most likely explains the elevated risk of prostate cancer with prior history of CIDs or use of AIMs, given the higher risk immediately after first CID event and lack of dose response. However, findings for length of time with asthma and dose of inhaled glucocorticoids suggest that asthma may increase risk of prostate cancer through other pathways.

Ort, förlag, år, upplaga, sidor
BioMed Central, 2019. Vol. 19, artikel-id 612
Nyckelord [en]
Prostate cancer, Chronic inflammatory disease, Autoimmune disease, Anti-inflammatory medication
Nationell ämneskategori
Cancer och onkologi
Identifikatorer
URN: urn:nbn:se:umu:diva-161512DOI: 10.1186/s12885-019-5846-3ISI: 000472477600005PubMedID: 31226970Scopus ID: 2-s2.0-85068501991OAI: oai:DiVA.org:umu-161512DiVA, id: diva2:1337208
Forskningsfinansiär
Cancerfonden, 2013/472Tillgänglig från: 2019-07-12 Skapad: 2019-07-12 Senast uppdaterad: 2023-03-24Bibliografiskt granskad

Open Access i DiVA

fulltext(1241 kB)315 nedladdningar
Filinformation
Filnamn FULLTEXT01.pdfFilstorlek 1241 kBChecksumma SHA-512
28aff012f9ab6ff1d79bf4636e344c8ab0bd6c0a968b80c0c4d4f2e73e9c41fdc4c47bad53f3124b2b3adb29d6b4dbdc056257c897c14583c6a7a77cef398431
Typ fulltextMimetyp application/pdf

Övriga länkar

Förlagets fulltextPubMedScopus

Person

Häggström, Christel

Sök vidare i DiVA

Av författaren/redaktören
Häggström, ChristelStattin, Pär
Av organisationen
Enheten för biobanksforskningUrologi och andrologi
I samma tidskrift
BMC Cancer
Cancer och onkologi

Sök vidare utanför DiVA

GoogleGoogle Scholar
Totalt: 315 nedladdningar
Antalet nedladdningar är summan av nedladdningar för alla fulltexter. Det kan inkludera t.ex tidigare versioner som nu inte längre är tillgängliga.

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 466 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf