High long-term test-retest reliability for extrastriatal 11C-raclopride binding in healthy older adultsShow others and affiliations
2020 (English)In: Journal of Cerebral Blood Flow and Metabolism, ISSN 0271-678X, E-ISSN 1559-7016, Vol. 40, no 9, p. 1859-1868Article in journal (Refereed) Published
Abstract [en]
In vivo dopamine D2-receptor availability is frequently assessed with 11C-raclopride and positron emission tomography. Due to low signal-to-noise ratios for 11C-raclopride in areas with low D2 receptor densities, the ligand has been considered unreliable for measurements outside the dopamine-dense striatum. Intriguingly, recent studies show that extrastriatal 11C-raclopride binding potential (BPND) values are (i) reliably higher than in the cerebellum (where D2-receptor levels are negligible), (ii) correlate with behavior in the expected direction, and (iii) showed good test-retest reliability in a sample of younger adults. The present work demonstrates high seven-month test-retest reliability of striatal and extrastriatal 11C-raclopride BPND values in healthy, older adults (n = 27, age: 64-78 years). Mean 11C-raclopride BPND values were stable between test sessions in subcortical nuclei, and in frontal and temporal cortices (p > 0.05). Across all structures analyzed, intraclass correlation coefficients were high (0.85-0.96), absolute variability was low (mean: 4-8%), and coefficients of variance ranged between 9 and 25%. Furthermore, regional 11C-raclopride BPND values correlated with previously determined 18F-fallypride BPND values (rho = 0.97 and 0.92 in correlations with and without striatal values, respectively, p < 0.01) and postmortem determined D2-receptor densities (including striatum: rho = 0.92; p < 0.001; excluding striatum: rho = 0.75; p = 0.067). These observations suggest that extrastriatal 11C-raclopride measurements represent a true D2 signal.
Place, publisher, year, edition, pages
Sage Publications, 2020. Vol. 40, no 9, p. 1859-1868
Keywords [en]
C-11-raclopride, binding potential, positron emission tomography, extrastriatal, reliability
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:umu:diva-164140DOI: 10.1177/0271678X19874770ISI: 000487160200001PubMedID: 31506011Scopus ID: 2-s2.0-85073987923OAI: oai:DiVA.org:umu-164140DiVA, id: diva2:1361900
2019-10-172019-10-172023-03-07Bibliographically approved