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High long-term test-retest reliability for extrastriatal 11C-raclopride binding in healthy older adults
Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI). Umeå University, Faculty of Medicine, Department of Radiation Sciences, Diagnostic Radiology.ORCID iD: 0000-0002-8603-9453
Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI). Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB).
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Diagnostic Radiology. Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI).ORCID iD: 0000-0002-4501-4735
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2020 (English)In: Journal of Cerebral Blood Flow and Metabolism, ISSN 0271-678X, E-ISSN 1559-7016, Vol. 40, no 9, p. 1859-1868Article in journal (Refereed) Published
Abstract [en]

In vivo dopamine D2-receptor availability is frequently assessed with 11C-raclopride and positron emission tomography. Due to low signal-to-noise ratios for 11C-raclopride in areas with low D2 receptor densities, the ligand has been considered unreliable for measurements outside the dopamine-dense striatum. Intriguingly, recent studies show that extrastriatal 11C-raclopride binding potential (BPND) values are (i) reliably higher than in the cerebellum (where D2-receptor levels are negligible), (ii) correlate with behavior in the expected direction, and (iii) showed good test-retest reliability in a sample of younger adults. The present work demonstrates high seven-month test-retest reliability of striatal and extrastriatal 11C-raclopride BPND values in healthy, older adults (n = 27, age: 64-78 years). Mean 11C-raclopride BPND values were stable between test sessions in subcortical nuclei, and in frontal and temporal cortices (p > 0.05). Across all structures analyzed, intraclass correlation coefficients were high (0.85-0.96), absolute variability was low (mean: 4-8%), and coefficients of variance ranged between 9 and 25%. Furthermore, regional 11C-raclopride BPND values correlated with previously determined 18F-fallypride BPND values (rho = 0.97 and 0.92 in correlations with and without striatal values, respectively, p < 0.01) and postmortem determined D2-receptor densities (including striatum: rho = 0.92; p < 0.001; excluding striatum: rho = 0.75; p = 0.067). These observations suggest that extrastriatal 11C-raclopride measurements represent a true D2 signal.

Place, publisher, year, edition, pages
Sage Publications, 2020. Vol. 40, no 9, p. 1859-1868
Keywords [en]
C-11-raclopride, binding potential, positron emission tomography, extrastriatal, reliability
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:umu:diva-164140DOI: 10.1177/0271678X19874770ISI: 000487160200001PubMedID: 31506011Scopus ID: 2-s2.0-85073987923OAI: oai:DiVA.org:umu-164140DiVA, id: diva2:1361900
Available from: 2019-10-17 Created: 2019-10-17 Last updated: 2023-03-07Bibliographically approved

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Karalija, NinaJonasson, Lars S.Johansson, JarkkoSalami, AlirezaAndersson, MicaelRiklund, KatrineNyberg, LarsBoraxbekk, Carl-Johan

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Karalija, NinaJonasson, Lars S.Johansson, JarkkoSalami, AlirezaAndersson, MicaelRiklund, KatrineNyberg, LarsBoraxbekk, Carl-Johan
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Umeå Centre for Functional Brain Imaging (UFBI)Diagnostic RadiologyDepartment of Integrative Medical Biology (IMB)Wallenberg Centre for Molecular Medicine at Umeå University (WCMM)Centre for Demographic and Ageing Research (CEDAR)
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Journal of Cerebral Blood Flow and Metabolism
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