Umeå universitets logga

umu.sePublikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Maternal blood folate status during early pregnancy and occurrence of autism spectrum disorder in offspring: a study of 62 serum biomarkers
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Pediatrik.ORCID-id: 0000-0002-0208-2877
Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Onkologi.ORCID-id: 0000-0002-2974-2003
Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap.
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Barn- och ungdomspsykiatri.
Visa övriga samt affilieringar
2020 (Engelska)Ingår i: Molecular Autism, ISSN 2040-2392, Vol. 11, artikel-id 7Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: Autism spectrum disorder (ASD) evolves from an interplay between genetic and environmental factors during prenatal development. Since identifying maternal biomarkers associated with ASD risk in offspring during early pregnancy might result in new strategies for intervention, we investigated maternal metabolic biomarkers in relation to occurrence of ASD in offspring using both univariate logistic regression and multivariate network analysis.

Methods: Serum samples from 100 women with an offspring diagnosed with ASD and 100 matched control women with typically developing offspring were collected at week 14 of pregnancy. Concentrations of 62 metabolic biomarkers were determined, including amino acids, vitamins (A, B, D, E, and K), and biomarkers related to folate (vitamin B9) metabolism, lifestyle factors, as well as C-reactive protein (CRP), the kynurenine-tryptophan ratio (KTR), and neopterin as markers of inflammation and immune activation.

Results: We found weak evidence for a positive association between higher maternal serum concentrations of folate and increased occurrence of ASD (OR per 1 SD increase: 1.70, 95% CI 1.22–2.37, FDR adjusted P = 0.07). Multivariate network analysis confirmed expected internal biochemical relations between the biomarkers. Neither inflammation markers nor vitamin D3 levels, all hypothesized to be involved in ASD etiology, displayed associations with ASD occurrence in the offspring.

Conclusions: Our findings suggest that high maternal serum folate status during early pregnancy may be associated with the occurrence of ASD in offspring. No inference about physiological mechanisms behind this observation can be made at the present time because blood folate levels may have complex relations with nutritional intake, the cellular folate status and status of other B-vitamins. Therefore, further investigations, which may clarify the potential role and mechanisms of maternal blood folate status in ASD risk and the interplay with other potential risk factors, in larger materials are warranted.

Ort, förlag, år, upplaga, sidor
BioMed Central, 2020. Vol. 11, artikel-id 7
Nyckelord [en]
Autism, Pregnancy, One-carbon metabolism, Folate, Vitamin B, Vitamin D, Vitamin A, Inflammation
Nationell ämneskategori
Psykiatri
Forskningsämne
psykiatri
Identifikatorer
URN: urn:nbn:se:umu:diva-167467DOI: 10.1186/s13229-020-0315-zISI: 000513660200001Scopus ID: 2-s2.0-85078358879OAI: oai:DiVA.org:umu-167467DiVA, id: diva2:1387544
Tillgänglig från: 2020-01-22 Skapad: 2020-01-22 Senast uppdaterad: 2024-07-02Bibliografiskt granskad

Open Access i DiVA

fulltext(1771 kB)356 nedladdningar
Filinformation
Filnamn FULLTEXT01.pdfFilstorlek 1771 kBChecksumma SHA-512
511f30031f97d3d98b93a7c55c158e027fb13888c89a5695198b3f2e9e1d0f7f1f0023578f26067efdbab117713bec4af972ee7e0d266efd34bc37b76ab7af9c
Typ fulltextMimetyp application/pdf

Övriga länkar

Förlagets fulltextScopus

Person

Egorova, OlgaMyte, RobinSchneede, JørnHägglöf, BrunoDomellöf, ErikIvars A'roch, BarbroElgh, FredrikSilfverdal, Sven-Arne

Sök vidare i DiVA

Av författaren/redaktören
Egorova, OlgaMyte, RobinSchneede, JørnHägglöf, BrunoDomellöf, ErikIvars A'roch, BarbroElgh, FredrikSilfverdal, Sven-Arne
Av organisationen
PediatrikOnkologiInstitutionen för farmakologi och klinisk neurovetenskapBarn- och ungdomspsykiatriInstitutionen för psykologiInstitutionen för klinisk mikrobiologi
I samma tidskrift
Molecular Autism
Psykiatri

Sök vidare utanför DiVA

GoogleGoogle Scholar
Totalt: 357 nedladdningar
Antalet nedladdningar är summan av nedladdningar för alla fulltexter. Det kan inkludera t.ex tidigare versioner som nu inte längre är tillgängliga.

doi
urn-nbn

Altmetricpoäng

doi
urn-nbn
Totalt: 839 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf