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Treatment of Restless legs with a pump: efficacy and complications
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Neurovetenskaper.
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Neurovetenskaper.ORCID-id: 0000-0003-3528-8502
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Neurovetenskaper.ORCID-id: 0000-0002-9552-2957
2020 (Engelska)Ingår i: Acta Neurologica Scandinavica, ISSN 0001-6314, E-ISSN 1600-0404, Vol. 141, nr 5, s. 368-373Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

OBJECTIVES: Restless legs (RLS) has a prevalence of 2.5-15 % in the general population.. For those who suffer from a medically refractory RLS, intrathecal morphine treatment has been shown to be effective. The aim of this retrospective study was to investigate efficacy, complications and side effects in patients treated over several years with an implantable pump. A comparison was done to a group of patients treated with a similar pump system due to spasticity.

MATERIALS AND METHODS: The charts of ten patients with severe or very severe RLS have been reviewed. These patients have received an intrathecal drug delivery system during 2000 -2016. To compare the rate of complications, a control group of 20 patients treated with intrathecal baclofen due to spasticity was included in the study. Their time of treatment corresponded to the RLS patients'.

RESULTS: The severity of symptoms related to RLS decreased significantly after treatment. Doses required ranged from 68 to 140 µg/day. Two cases of side effects were detected; one case with nausea and dizziness and one case with headache and fatigue. The rate of mechanical-, infectious- and other complications were similar between the two groups.

CONCLUSIONS: In light of the decrease in symptom severity and the low rate of side effects, intrathecal morphine can be considered an adequate treatment for those suffering from medically refractory RLS. The occurrence of complications did not differ between subjects with RLS and spasticity.

Ort, förlag, år, upplaga, sidor
John Wiley & Sons, 2020. Vol. 141, nr 5, s. 368-373
Nyckelord [en]
Intrathecal Morphine, Restless legs, complications
Nationell ämneskategori
Neurologi
Forskningsämne
neurokirurgi
Identifikatorer
URN: urn:nbn:se:umu:diva-167469DOI: 10.1111/ane.13213ISI: 000508902400001PubMedID: 31883387Scopus ID: 2-s2.0-85078746572OAI: oai:DiVA.org:umu-167469DiVA, id: diva2:1387695
Tillgänglig från: 2020-01-22 Skapad: 2020-01-22 Senast uppdaterad: 2023-03-23Bibliografiskt granskad

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Koskinen, Lars-Owe D.Lindvall, Peter

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