Balance between Transmitter Availability and Dopamine D2 Receptors in Prefrontal Cortex Influences Memory FunctioningShow others and affiliations
2020 (English)In: Cerebral Cortex, ISSN 1047-3211, E-ISSN 1460-2199, Vol. 30, p. 989-1000Article in journal (Refereed) Published
Abstract [en]
Insufficient or excessive dopaminergic tone impairs cognitive performance. We examine whether the balance between transmitter availability and dopamine (DA) D2 receptors (D2DRs) is important for successful memory performance in a large sample of adults (n = 175, 64-68 years). The Catechol-O-Methyltransferase polymorphism served as genetic proxy for endogenous prefrontal DA availability, and D2DRs in dorsolateral prefrontal cortex (dlPFC) were measured with [11C]raclopride-PET. Individuals for whom D2DR status matched DA availability showed higher levels of episodic and working-memory performance than individuals with insufficient or excessive DA availability relative to the number of receptors. A similar pattern restricted to episodic memory was observed for D2DRs in caudate. Functional magnetic resonance imaging data acquired during working-memory performance confirmed the importance of a balanced DA system for load-dependent brain activity in dlPFC. Our data suggest that the inverted-U-shaped function relating DA signaling to cognition is modulated by a dynamic association between DA availability and receptor status.
Place, publisher, year, edition, pages
Oxford University Press, 2020. Vol. 30, p. 989-1000
Keywords [en]
catechol-O-methyltransferase, [11C] raclopride, dopamine D2 receptors, episodic memory, working memory
National Category
Neurology
Identifiers
URN: urn:nbn:se:umu:diva-169317DOI: 10.1093/cercor/bhz142ISI: 000535899500011PubMedID: 31504282Scopus ID: 2-s2.0-85083042258OAI: oai:DiVA.org:umu-169317DiVA, id: diva2:1420712
Funder
Swedish Research CouncilKnut and Alice Wallenberg FoundationTorsten Söderbergs stiftelseRagnar Söderbergs stiftelseThe Swedish Brain FoundationVästerbotten County CouncilMax Planck Society2020-03-312020-03-312023-03-24Bibliographically approved